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Free Radicals, Lipoproteins, and Membrane Lipids

  • Book
  • © 1990

Overview

Editors:
  1. A. Crastes Paulet

    1. INSERM Unit 58, Montpellier, France

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  2. L. Douste-Blazy

    1. INSERM Unit 101, Toulouse, France

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    You can also search for this editor in PubMed   Google Scholar

  3. R. Paoletti

    1. University of Milan, Milan, Italy

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 189)

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Table of contents (36 chapters)

  1. Front Matter

    Pages i-ix
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  2. Free Radical Production Mechanisms

    1. Front Matter

      Pages xi-xi
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    2. Radical Mechanisms in Fatty Acid and Lipid Peroxidation

      • Wolf Bors, Michael Erben-Russ, Christa Michel, Manfred Saran
      Pages 1-16

    3. Lipid Peroxidation by Phagocytes

      • Bernard M. Babior
      Pages 17-21

    4. Triggering and Regulation of the Free Radical Production by Phagocytes

      • P. Bellavite, M. C. Serra, F. Bazzoni, S. Miron, S. Dusi
      Pages 23-44

    5. Two Structurally Unrelated PAF Antagonists, BN 52021 and BN 52111, Partially Inhibit TNF-Induced Superoxide Release by Human Neutrophils

      • Monique Paubert-Braquet, David Hosford, Philipe Koltz, Jean Guilbaud, Pierre Braquet
      Pages 45-53

    6. Membrane Glycoproteins in Superoxide Release from Neutrophils

      • Giovanni Ricevuti, Antonino Mazzone, Antonia Notario
      Pages 55-63

    7. Free Radical Production by the Mitochondrion

      • Julio F. Turrens, Joe M. McCord
      Pages 65-71

    8. Hemoglobin as a Promoter of Central Nervous System Damage

      • John W. Eaton, Douglas A. Peterson, S. M. H. Sadrzadeh
      Pages 73-79

    9. Role of Xanthine Oxidase and Granulocytes in Ischemia/Reperfusion Injury

      • Matthew B. Grisham, Barbara J. Zimmerman, D. Neil Granger
      Pages 81-88

    10. Evidence for Free Radical Generation in Vivo during Cardiac Ischemia and Reperfusion

      • Roberto Bolli, Bharat S. Patel, Mohamed O. Jeroudi, Edward K. Lai, Paul B. McCay
      Pages 89-97

    11. Superoxide Generation by Clastogenic Factors

      • Ingrid Emerit, Arlette Levy, Shahid Khan
      Pages 99-104

  3. Chemistry of Free Radical Effects

    1. Front Matter

      Pages N1-N1
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    2. Degradation of Membrane Phospholipids by a Direct Nucleophilic Action of Superoxide Anion

      • C. Deby, M. Boes, J. Pincemail, J. Bourdon-Neuray, G. Deby-Dupont
      Pages 105-113

    3. Mechanisms of Formation of Oxysterols: A General Survey

      • Leland L. Smith
      Pages 115-132

    4. Role of Oxygen and of Superoxide Radical in the Mechanisms of Monoelectronic Activation of Various Xenobiotics : A Radiolysis Study

      • Monique Gardès-Albert, Chantal Houée-Levin, Abdelhafid Sekaki, Christiane Ferradini
      Pages 133-142

  4. Methods of Measurement

    1. Front Matter

      Pages N3-N3
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    2. Methods of Measuring Lipid Peroxidation in Biological Systems: An Overview

      • Kevin H. Cheeseman
      Pages 143-152

    3. Measurement of Superoxide and Superoxide Dismutase by Electron Spin Resonance and Chemiluminescence Assay

      • Toshikazu Yoshikawa, Yuji Naito, Toru Tanigawa, Shigeru Sugino, Motoharu Kondo
      Pages 153-162

    4. Pentane Measurement, an Index of in Vivo Lipoperoxidation: Applications and Limits of the Method

      • J. Pincemail, C. Deby, M. Lismonde, Y. Bertrand, G. Camus, M. Lamy
      Pages 163-169
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Keywords

About this book

This book contains the proceedings of the ARW NATO Conference on "Action of Free Radicals and Active Forms of Oxygen on Lipoproteins and Membrane Lipids: Cellular Interactions and Atherogenesis", held in Bendor, France, October 5-8,1988. Since the pioneer work of Mc Cord and Fridovitch, growing interest has been focused on the study of the role of oxyradicals role in pathology. This interest is reflected in the exponential increase in the number of papers on free radicals, the success of specialized journals and books on this theme, and the organization of national and international meetings. These meetings have discussed, from.a broad point of view, the problems concerning the mechanisms of production of free radicals, their effects on cell CO!1$tituants (lipids, proteins, nucleic acids) and cell function, the methods of analysis of these phenomena, the pathological states in which free radicals may be involved, natural biological defense systems, and the design of "antiradical" therapies. But it is now well established that the most common target of oxy free radicals are membrane lipids because of their chemical nature (cholesterol in saturation, malonic linkage of polyunsaturated fatty acids (PUFA» and of their regular structural arrangement (monolayers in lipoproteins, bilayers in cell membranes). Thus the analysis of the products resulting from the action of oxy free radicals on PUFA is considered the best tool to indirectly evaluate the effects of tissue peroxidations, although the analytical basis for doing so is very questionable.

Editors and Affiliations

  • INSERM Unit 58, Montpellier, France

    A. Crastes Paulet

  • INSERM Unit 101, Toulouse, France

    L. Douste-Blazy

  • University of Milan, Milan, Italy

    R. Paoletti

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