Abstract
Chromosome breakage factors or clastogenic factors (CF) were first described by radiobiologists, who reported a chromosome damaging effect of plasma from irradiated persons (for review see 1). These authors insisted on the long lasting nature of this phenomenon and suggested that CF may be risk factors in the development of late neoplasias resulting from therapeutic or accidental irradiaton. Renewed interest in diffusable CF paralleled the recognition of clastogenic activity in the plasma of patients with the socalled congenital breakage syndromes, ataxia telangiectasia (2) and Bloom’s syndrome (3), and in acquired diseases with increased chromosome damage, such as chronic inflammatory diseases of the connective tissue, the intestinal tract and the nervous system (for review see 4). CF may be isolated not only from plasma, but also from synovial fluid and cerebrospinal liquor.
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References
G.B. Faguet, S.M. Reichard and D.A. Welter. radiation-induced clastogenic plasma factors. Cancer Genetics and Cytogenetic, 12: 73–83 (1984).
M.Shaham, Y. Becker and M.M. Cohen. A diffusable clastogenic factor in ataxia telangiectasia. Cytogenetic, cell genetic, 27: 155–161 (1980).
I. Emerit and P. Cerutti. Clastogenic activity from Bloom’s fibroblast cultures. Proc. Natl. Acad. Sci. USA, 78: 1868–1872 (1981).
I. Emerit. Chromosome breakage factors: origin and possible significance. Progr. Mutat. Res., 4: 61–74 (1982).
I. Emerit. Oxygen-derived free radicals and DNA damage in autoimmune diseases, in “Free Radicals, Aging and Degenerative Diseases.”, J.E. Johnson ed. Alan R.Liss, New York pages 307–324 (1986).
S.H. Khan and I. Emerit. Lipid peroxidation products and clastogenic material in culture media of human leukocytes exposed to the tumor promoter phorbol-myristate acetate. J.Free Rad. Biol. Med. 1: 443–449 (1985).
I. Emerit, S.H. Khan, and P. Cerutti. Treatment of lymphocyte cultures with a hypoxanthine–xanthine oxidase system induces the formation of transferable clastogenic material. J.Free Rad. Biol. Med. 1: 51–57 (1985).
I. Emerit, J.N. Fabiani, O. Ponzio, A. Murday, F. Lunel, A. Carpentier. Clastogenic factor in ischemia-reperfusion. The Annals of Thoracic Surgery, in press.
B.Johnston. Measurment of 02; secreted by monocytes and macrophages. In “Methods in Enzymology”, L.Packer ed. Academic Press Inc. New York 105: 215–220 (1984).
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© 1990 Plenum Press, New York
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Emerit, I., Levy, A., Khan, S. (1990). Superoxide Generation by Clastogenic Factors. In: de Paulet, A.C., Douste-Blazy, L., Paoletti, R. (eds) Free Radicals, Lipoproteins, and Membrane Lipids. NATO ASI Series, vol 189. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7427-5_10
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DOI: https://doi.org/10.1007/978-1-4684-7427-5_10
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