Overview
- Editors:
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Kiyonobu Mikanagi
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Mikanagi Gotanda Hospital, Tokyo, Japan
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Kusuki Nishioka
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Tokyo Women’s Medical College, Tokyo, Japan
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William N. Kelley
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University of Michigan Medical Center, Ann Arbor, USA
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Table of contents (89 chapters)
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Muscle and Purine Metabolsim
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- Masashi Ogasawara, Tetsuya Seino, Shinji Hadano, Akira Ito, Hiroshi Goto, Mitsuo Itakura
Pages 369-374
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- Takao Shimizu, Norio Kono, Hiroaki Kiyokawa, Yuya Yamada, Naoko Hara, Ikuo Mineo et al.
Pages 375-379
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- Naoko Hara, Ikuo Mineo, Norio Kono, Hiroaki Kiyokawa, Masanori Kawachi, Yuya Yamada et al.
Pages 381-386
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Purine Metabolism in Human Tissue
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- Giovanni Ronca, Angela Conte, Simonetta Ronca-Testoni, Riccardo Zucchi, Rosa Poddighe, Rita Mariotti et al.
Pages 387-391
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- Robert L. Wortmann, Judith A. Veum, John W. Rachow
Pages 393-398
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- Kari O. Raivio, Kim Vettenranta
Pages 399-406
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- Enrico Marinello, Daniela Vannoni, Brunetta Porcelli, Egidio Dispensa
Pages 407-410
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- A. Giacomello, C. Salerno, P. Cardelli, M. C. Santulli, A. Rossi, R. Strom
Pages 411-415
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- Tadashi Ikegami, Yutaka Natsumeda, George Weber
Pages 417-421
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- Hiroshi Tsutani, Teruo Yoshimura, Michihiko Uchida, Kenichi Kamiya, Takanori Ueda, Toru Nakamura
Pages 423-426
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Anti-Cancer Purine and Pyrimidine Analogs Clinical Aspects
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- Dennis A. Carson, Lawrence D. Piro, D. Bruce Wasson, Carlos J. Carrera, Ernest Beutler
Pages 427-431
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- Yolanda M. T. Marijnen, Dirk de Korte, Dirk Roos, Albert H. van Gennip
Pages 433-438
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- Godefridus J. Peters, Emile J. Laurensse, Cees J. van Groeningen, Sybren Meijer, Herbert M. Pinedo
Pages 439-445
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- R. Pieters, D. R. Huismans, A. Leyva, A. J. P. Veerman
Pages 447-454
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- Tomoko Hasunuma, Hisashi Yamanaka, Chihiro Terai, Nobuyuki Miyasaka, Naoyuki Kamatani, Kusuki Nishioka et al.
Pages 455-460
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Molecular Genetics of Purine and Pyrimidine Enzymes
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- Nobuaki Ogasawara, Haruko Goto
Pages 461-465
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- Milton W. Taylor, Joo-Hung Park, De-Chu Tang
Pages 467-473
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- Howard V. Hershey, Milton W. Taylor
Pages 475-480
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- Hiromu Nakajima, Tamio Noguchi, Ikuo Mineo, Tomoyuki Yamasaki, Norio Kono, Takehiko Tanaka et al.
Pages 485-491
About this book
These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan ,July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.
Editors and Affiliations
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Mikanagi Gotanda Hospital, Tokyo, Japan
Kiyonobu Mikanagi
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Tokyo Women’s Medical College, Tokyo, Japan
Kusuki Nishioka
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University of Michigan Medical Center, Ann Arbor, USA
William N. Kelley