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Central Neurotransmitter Turnover

  • Book
  • © 1981

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Editors:
  1. C. J. Pycock
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    You can also search for this editor in PubMed   Google Scholar

  2. P. V. Taberner
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Table of contents (13 chapters)

  1. Front Matter

    Pages i-vii
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  2. Turnover of Central Neurotransmitters

    1. Front Matter

      Pages n1-n1
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    2. Turnover of Neurotransmitters in the Brain: An Introduction

      • J. Korf
      Pages 1-19

    3. The Turnover of Catecholamines

      • D. F. Sharman
      Pages 20-58

    4. The Turnover of 5-Hydroxytryptamine

      • G. Curzon
      Pages 59-80

    5. The Turnover of Acetylcholine

      • G. B. Ansell
      Pages 81-104

    6. The Turnover of Transmitter Amino Acids, with Special Reference to GABA

      • F. Fonnum
      Pages 105-124

    7. The Turnover of Neuropeptides

      • A. Harmar, P. Keen
      Pages 125-142

  3. Application of Turnover Studies to Specific Problems

    1. Front Matter

      Pages n3-n3
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    2. Differences in Dopamine Metabolism in Rat Striatum and Olfactory Tubercle

      • Henk J. Broxterman, Cees F. M. van Valkenburg, Eric L. Noach
      Pages 143-148

    3. Changes in Central 5-Hydroxytryptamine Turnover Induced by Acute and Chronic Inhibition of the Re-Uptake Process

      • G. L. Diggory, S. E. Dickison, M. D. Wood, M. G. Wyllie
      Pages 149-154

    4. Tail Pinch Induced Gnawing: Voltammetric and Behavioural Effects of Fenfluramine

      • P. H. Hutson, P. J. Knott, G. Curzon
      Pages 155-161

    5. Analysis of CSF Amine Metabolites and Precursors including Tryptophan, 5HIAA and HVA by HPLC using Fluorescence and Electrochemical Detection in Primates: Effect of Probenecid

      • M. H. Joseph, H. F. Baker, R. M. Ridley
      Pages 162-167

    6. Species Differences in the Acetylation of [3H] Choline in Cortical Slices

      • C. K. Atterwill, A. K. Prince, R. Reynolds, P. T.-H. Wong
      Pages 168-176

    7. The Effects of GABA Uptake Inhibitors including 2, 4-Diaminobutyric Acid on GABA Metabolism in vivo

      • P. V. Taberner, C. J. Pycock
      Pages 177-182

    8. Concomitant Determination of Endogenous Release of Dopamine, Noradrenaline, 5-Hydroxytryptamine and Thyrotrophin Releasing Hormone (TRH) from Rat Brain Slices and Synaptosomes

      • G. W. Bennett, C. A. Marsden, T. Sharp, J. F. Stolz
      Pages 183-189

  4. Back Matter

    Pages 191-197
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Keywords

About this book

The concept of chemical transmission in the central nervous system has taken some time to be generally accepted, but an increasing number of compounds are now being recognized as hav­ ing a transmitter role in the brain. The acetylcholine system was the first to be discovered in the periphery and its charac­ teristic features of storage of transmitter in vesicles in the nerve terminal, its electrically-evoked release and rapid extra­ neuronal breakdown were considered to be necessary criteria for any neurotransmitter candidate. The subsequent elucidation of the noradrenergic system made it apparent that rapid enzymatic breakdown was not essential for a released transmitter, and the possibility of high-affinity re-uptake processes became establ­ ished as an alternative means of terminating the synaptic actions of a transmitter. With the eventual acceptance of the amino acids as excitat­ ory or inhibitory transmitters, the requirement for a transmit­ ter to be present in a low concentration overall (although locally concentrated in specific terminals) also had to be discarded. This necessitated the additional concept of specif­ ic metabolic pools with different functions being located in different cells or within different regions of the same cell. Some localization of glutamate and aspartate remote from excit­ able membranes is clearly essential since their overall brain concentrations would be sufficient to maximally depolarize the majority of neurones in the brain. The concept of separate metabolic pools has been supported by stUdies on turnover rate (see Chapter 5).

Bibliographic Information

  • Book Title: Central Neurotransmitter Turnover

  • Editors: C. J. Pycock, P. V. Taberner

  • DOI: https://doi.org/10.1007/978-1-4615-9778-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: C.J. Pycock and P.V. Taberner 1981

  • Softcover ISBN: 978-1-4615-9780-3Published: 30 January 2012

  • eBook ISBN: 978-1-4615-9778-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VII, 197

  • Number of Illustrations: 6 b/w illustrations

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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