Abstract
Regional differences in drug effects on dopamine (DA) turnover are often taken as indications for differential effects in functional activity of the various dopaminergic systems. Functional activity of central dopaminergic neurones may be estimated by measurement of the levels of the acidic DA metabolites, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) (Roth et al., 1976). Another frequently used method is the estimation of DA decay after inhibition of its synthesis with α-methyl-p-tyrosine (aMpT) (Andén et al.,1971, see Sharman this volume). However, these two indices of dopaminergic nerve activity do not always give concordant results (Waldmeier & Maftre, 1976; Wuerthele & Moore, 1979).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andén, N.-E., Corrodi, H., Fuxe, K. & Ungerstedt U. (1971) Importance of nervous impulse flow for the neuroleptic induced increase in amine turnover in central dopaminergic neurons.Eur. J. Pharmacol. 15, 193–199.
Broxterman, H.J., Noach, E.L., & Van Valkenburg C.F.M. (1979) Differential effects of acute and subacute HA-966 treatment on storage and release of striatal dopamine. Eur. J. Pharmacol. 60, 153–161.
Broxterman, H.J., Van Valkenburg, C.F.M. & Noach E.L. (1980) HA-966 effects on striatal dopamine metabolism: implications for dopamine compartmentalization. J. Pharm. Pharmacol. 32, 67–69.
Hirano, M., Kim, J.S., Saito, M., Uchimura, H., Ito M. & Nakahara T. (1978) Monoamine oxidase activities for serotonin and tyramine in individual limbic and lower brain stem nuclei of the rat. J. Neurochem. 30, 263–267.
Kehr, W. (1974) Temporal changes in catecholamine synthesis of rat forebrain structures after axotomy. J. Neural Transm. 35,307 –317.
Lisoprawski, A., Hervé, D., Blanc, G., Glowinski, J. & Tassin, J.P. (1980) Selective activation of the mesocorticalfrontal dopaminergic neurons induced by lesion of the habenula in the rat. Brain Res. 183, 229–234.
Mos J., & Van Valkenburg C.F.M. (1979) Specific effect of social stress and aggression on regional dopamine metabolism in rat brain. Neuroscience Lett. 15, 325–327.
Nowycky, M.C., & Roth, R.H. (1977) Reversible lesion of central dopaminergic neurons with l-hydroxy-3-amino-pyrrolidone-2. 8th Annual meeting of the Am. Soc. Neurochem. Abstract 72.
Papeschi R. (1977) The functional pool of brain catecholamines: its size and turnover rate. Psychopharmacology, 55, 1–7.
Roth R.H., Murrin L.C. & Walters J.R. (1976) Central dopaminergic neurons: effects of alterations in impulse flow on the accumulation of dihydroxyphenylacetic acid. Eur. J. Pharmacol. 36, 163–171.
Roth R.H., Walters, J.R., & Aghajanian, O.K. (1973) Effects of impulse flow on the release and synthesis of dopamine in rat striatum. In: Frontiers in Catecholamine Research (Usdin E. & Snyder S.H., eds). pp. 567–574. Pergamon Press, Oxford & New York.
Scatton, B., Glowinski, J., & Julou L. (1976) Dopamine metabolism in the mesolimbic and mesocortical dopaminergic system systems after single or repeated adminstration of neuroleptics. Brain Res. 109, 184–192.
Thierry, A.M., Tassin J.P., Blanc, G., & Glowinski, J. (1976) Selective activation of the mesocortical dopaminergic system by stress. Nature (Lond). 263, 242–244.
Waldmeier P.C., & Maître L. (1976) On the relevance of preferential increase of mesolimbic versus striatal dopamine turnover for the prediction of antipsychotic activity of psychotropic drugs. J. Neurochem. 27, 589–597.
Westerink B.H.C., & Korf, J. (1976) Turnover of acid dopamine metabolites in striatal and mesolimbic tissue of the rat brain. Eur. J. Pharmacol. 37, 249–255.
Westerink, B.H.C., & Korf J. (1977) Rapid concurrent automated fluorimetric assay of noradrenaline, dopamine, 3, 4-dihydroxyphenylacetic acid, homovanillic acid and 3-methoxytyramine in milligram amounts of nervous tissue after isolation on Sephadex G-10. J. Neurochem. 29, 697–706.
Wuerthele S.M., & Moore K.E. (1979) Effects of dopaminergic antagonists on striatal DOPAC concentrations and α-methyl-p-tyrosine-induced decline of dopamine following intrastriatal injections of kainic acid. J. Pharm. Pharmacol. 31, 180–182.
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1981 C.J. Pycock and P.V. Taberner
About this chapter
Cite this chapter
Broxterman, H.J., van Valkenburg, C.F.M., Noach, E.L. (1981). Differences in Dopamine Metabolism in Rat Striatum and Olfactory Tubercle. In: Pycock, C.J., Taberner, P.V. (eds) Central Neurotransmitter Turnover. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9778-0_7
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9778-0_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9780-3
Online ISBN: 978-1-4615-9778-0
eBook Packages: Springer Book Archive