Overview
- Editors:
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J. Richard Hinchliffe
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University College of Wales, Aberystwyth, Wales, UK
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Juan M. Hurle
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University of Cantabria, Santander, Spain
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Dennis Summerbell
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National Institute for Medical Research, London, UK
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Table of contents (54 chapters)
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The Molecular Basis of Patterning
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Pattern of Gene Expression
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- Robert E. Hill, Duncan R. Davidson
Pages 15-23
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- Patricia A Blundell, Jose-Luis de la Pompa, J. H. Carel Meijers, Andreas Trumpp, Rolf Zeller
Pages 25-30
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- Robin Brown, Jeremy P. Brockes
Pages 31-35
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- Robert A. Kosher, William B. Upholt, Caroline N. D. Coelho, Kimberly J. Blake, Lauro Sumoy
Pages 37-43
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- Clifford J. Tabin, Bruce Morgan, Hans-Georg Simon, Sara Lazar, Yaoqui Wang, Anuradha Iyer et al.
Pages 45-54
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- G. Lyons, K. Krabbenhoft, B. K. Simandl, M. Buckingham, J. Fallon, B. Robert
Pages 55-56
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- Berend von Thülen, Reinhold Janocha, Jürgen Niessing
Pages 57-59
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- Marie-Andrée Akimenko, Marc Ekker, Monte Westerfield
Pages 61-63
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Retinoids, Receptors and Gene Expression
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- Pascal Dollé, Esther Ruberte, Juan-Carlos Izpisùa-Belmonte, Hildegard Falkenstein, Pierre Chambon, Denis Duboule
Pages 65-73
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- P. Kastner, N. Brand, A. Krust, P. Leroy, C. Mendelsohn, M. Petkovich et al.
Pages 75-88
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- Malcolm Maden, Nick Waterson, Dennis Summerbell, Jean Maignon, Michel Darmon, Braham Shroot
Pages 89-96
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- Annie Rowe, Joy M. Richman, James O. Ochanda, Paul M. Brickell
Pages 97-100
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- Annie Rowe, Nicholas S. C. Eager, Melanie Saville, Lewis Wolpert, Paul M. Brickell
Pages 101-104
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Growth and Pattern, Retinoids and Other Factors
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- Hiroyuki Ide, Yasushi Ohkubo, Sumihare Noji, Shigehiko Taniguchi
Pages 105-113
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- Reinhold Janocha, Gregor Eichele
Pages 123-132
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- S. V. Bryant, T. Hayamizu, N. Wanek, D. M. Gardiner
Pages 133-142
About this book
Following pioneering work by Harrison on amphibian limbs in the 1920s and by Saunders (1948) on the apical ridge in chick limbs, limb development became a classical model system for investigating such fundamental developmental issues as tissue interactions and induction, and the control of pattern formation. Earlier international conferences, at Grenoble 1972, Glasgow 1976,and Storrs, Connecticut 1982, reflected the interests and technology of their time. Grenoble was concerned with ectoderm-mesenchyme interaction, but by the time of the Glasgow meeting, the zone of polarizing activity (ZPA) and its role in control of patterning was the dominant theme. Storrs produced the first intimations that the ZPA could be mimicked by retinoic acid (RA), but the diversity of extracellular masrix ~olecules,particularly in skeletogenesis,was the main focus of attention. By 1990, the paradigms had again shifted. Originally, the planners of the ARW saw retinoic acid (as a possible morphogen controlling skeletal patterning), the variety of extracellular matrix components and their roles, and the developmental basis of limb evolution as the leading contemporary topics. However, as planning proceeded, it was clear that the new results emerging from the use of homeobox gene probes (first developed to investigate the genetic control of patterning of Drosophila embryos) to analyse the localised expression of "patterning genes" in limb buds would also be an important theme.
Editors and Affiliations
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University College of Wales, Aberystwyth, Wales, UK
J. Richard Hinchliffe
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University of Cantabria, Santander, Spain
Juan M. Hurle
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National Institute for Medical Research, London, UK
Dennis Summerbell