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Biochemical and Molecular Aspects of Retinoid Action in Limb Pattern Formation

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Developmental Patterning of the Vertebrate Limb

Part of the book series: NATO ASI Series ((NSSA,volume 205))

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Abstract

Retinoids are a class of naturally occurring compounds consisting of a hydrocarbon ring linked to an unsaturated hydrocarbon side chain with a polar terminal group. Retinoids have dramatic effects on differentiation and development. For example, retinoic acid (RA) alters positional identity in developing and regenerating systems: in the chick limb bud the anteroposterior axis is affected by locally applied RA (Tickle et al. 1982, 1985; Summerbell, 1983) and systemic and/or exogenous treatment with RA changes the rostrocaudal axis of Xenopus (Durston et al., 1989; Sive et al., 1990) and the proximodistal axis of the regenerating urodele limb (Maden, 1982; Thorns and Stocum, 1984).

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Authors and Affiliations

  1. Department of Cellular and Molecular Physiology, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA

    Reinhold Janocha & Gregor Eichele

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  1. Reinhold Janocha
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  2. Gregor Eichele
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Editors and Affiliations

  1. University College of Wales, Aberystwyth, Wales, UK

    J. Richard Hinchliffe

  2. University of Cantabria, Santander, Spain

    Juan M. Hurle

  3. National Institute for Medical Research, London, UK

    Dennis Summerbell

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© 1991 Springer Science+Business Media New York

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Janocha, R., Eichele, G. (1991). Biochemical and Molecular Aspects of Retinoid Action in Limb Pattern Formation. In: Hinchliffe, J.R., Hurle, J.M., Summerbell, D. (eds) Developmental Patterning of the Vertebrate Limb. NATO ASI Series, vol 205. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3310-8_18

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  • DOI: https://doi.org/10.1007/978-1-4615-3310-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6457-3

  • Online ISBN: 978-1-4615-3310-8

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