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DNA Damage and Repair in Human Tissues

  • Book
  • © 1990

Overview

Editors:
  1. Betsy M. Sutherland

    1. Brookhaven National Laboratory, Upton, USA

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  2. Avril D. Woodhead

    1. Brookhaven National Laboratory, Upton, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Basic Life Sciences (BLSC, volume 53)

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Table of contents (33 chapters)

  1. DNA Damage and Repair in Human Blood Cells

    1. Peripheral Blood Leukocytes as a Surrogate Marker for Cisplatin Drug Resistance: Studies of Adduct Levels and the Repair Gene ERCC1

      • Ricardo J. Parker, Miriam C. Poirier, Freida Bostick-Bruton, Justine Vionnet, Vilhelm A. Bohr, Eddie Reed
      Pages 251-261

    2. Factors Which Affect DNA Repair in Human Lymphocytes

      • L. L. Larcom, M. E. Smith, T. E. Morris
      Pages 263-276

    3. Methyl Transferase Activity in Secondary Leukemia

      • Bernard Strauss, Daphna Sagher, Theodore Karrison, Jeffrey Schwartz, Richard Larson, Stephanie Williams
      Pages 277-289

    4. The Single Cell Gel Assay: A Sensitive Technique for Evaluating Intercellular Differences in DNA Damage and Repair

      • R. R. Tice, P. W. Andrews, N. P. Singh
      Pages 291-301

  2. Detection and Analysis of Human Mutations

    1. Cytogenetic Investigations of DNA Damage in Aging: A Twin Study

      • Betsy Hirsch
      Pages 303-313

    2. Studies of DNA Alterations in In Vivo Somatic Cell Mutations in Humans

      • Richard J. Albertini, Janice A. Nicklas, J. Patrick O’Neill
      Pages 315-328

    3. Mechanisms of Induction of Specific Chromosomal Alterations

      • R. Julian Preston
      Pages 329-336

    4. Unfolding Perspectives on the Genetic Effects of Human Exposures to Radiation

      • James V. Neel
      Pages 337-349

    5. Effects of Caloric Restriction on the Maintenance of Genetic Fidelity

      • Ronald W. Hart, Angelo Turturro, Rex A. Pegram, Ming W. Chou
      Pages 351-361

  3. Internal Organs

    1. Oncogenes and Tumor Suppressor Genes Involved in Human Lung Carcinogenesis

      • Curtis C. Harris, Roger Reddel, Rama Modali, Teresa A. Lehman, Deborah Iman, Mary McMenamin et al.
      Pages 363-379

    2. Activation of Carcinogens by Human Liver Cytochromes P-450

      • F. Peter Guengerich, Tsutomu Shimada, Masahiko Iwasaki, Mary Ann Butler, Fred F. Kadlubar
      Pages 381-396

    3. Repair of O6-Methylguanine Damage in Normal Human Tissues

      • Steven M. D’Ambrosio, Gulzar Wani, Mervyn Samuel, Ruth Gibson-D’Ambrosio, Altaf A. Wani
      Pages 397-416

    4. Repair of O4-Alkylthymine Damage in Human Cells

      • Altaf A. Wani, Gulzar Wani, Steven M. D’Ambrosio
      Pages 417-435

    5. Alkylation Repair in Human Tissues

      • R. Montesano, J. Hall, M. Hollstein, N. Mironov, C. P. Wild
      Pages 437-452

  4. Back Matter

    Pages 453-464
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Keywords

About this book

Physical and chemical agents in the environment damage the DNA of humans, and pose a major threat to human health today, and to the genetic integrity of human populations. Although studies on isolated DNA in vitro, on prokaryotes, on mammalian cells in culture, and on laboratory animals have provided essential background information, it is now possible to study DNA damage and repair in human tissues directly. New techniques of high sensitivity, especially those not requiring radioactive labeling have made possible quantitation of DNA damage and repair, as well as detection of residual, unrepaired DNA lesions . In recent years, several investigators have taken up the challenge of studying damage and repair responses in humans, and we have chosen that work as the special focus of this Symposium. Major advances in under­ standing damage and responses in human skin, in blood cells and in human internal organs indicate three major themes. First, DNA damage levels in human tissues depend not only on the initial exposures, but also on the capapacity of that tissue for repair of the specific lesion type. Second, repair in human tissues may differ quantitatively and qualitatively from that in human cells in culture.

Editors and Affiliations

  • Brookhaven National Laboratory, Upton, USA

    Betsy M. Sutherland, Avril D. Woodhead

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