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Post‑Transcriptional Regulation by STAR Proteins

Control of RNA Metabolism in Development and Disease

  • Book
  • © 2010

Overview

Editors:
  1. Talila Volk

    1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

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  2. Karen Artzt

    1. Department of Molecular Genetics and Microbiology, Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, USA

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  • Reviews the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets
  • Overviews of the post-translational modifications of STAR proteins and their effects on biological functions
  • Reviews what is known about STAR proteins and human disease including osteoporosis, schizophrenia, cancer, infertility and ataxia

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 693)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Star Trek

    • Karen Artzt, Jiang I. Wu
    Pages 1-24

  3. The Star Family Member

    • Yue Feng, Andrew Bankston
    Pages 25-36

  4. Insights into the Structural Basis of RNA Recognition by Star Domain Proteins

    • Sean P. Ryder, Francesca Massi
    Pages 37-53

  5. Post-translational Regulation of STAR Proteins and Effects on Their Biological Functions

    • Claudio Sette
    Pages 54-66

  6. Expression and Functions of the Star Proteins Sam68 and t-star in Mammalian Spermatogenesis

    • Ingrid Ehrmann, David J. Elliott
    Pages 67-81

  7. The Role of Quaking in Mammalian Embryonic Development

    • Monica J. Justice, Karen K. Hirschi
    Pages 82-92

  8. Drosophila STAR Proteins

    • Talila Volk
    Pages 93-105

  9. C. Elegans Star Proteins, Gld-1 And Asd-2, Regulate Specific RNA Targets to Control Development

    • Min-Ho Lee, Tim Schedl
    Pages 106-122

  10. The Branchpoint Binding Protein

    • Brian C. Rymond
    Pages 123-141

  11. Reaching for the STARs

    • Stéphane Richard
    Pages 142-157

  12. Back Matter

    Pages 159-162
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Keywords

Editors and Affiliations

  • Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

    Talila Volk

  • Department of Molecular Genetics and Microbiology, Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, USA

    Karen Artzt

About the editors

Talila Volk is an associate professor in the field of Developmental Biology and the incumbent of the Sir Ernest B. Chain Professional Chair. Her major research interest is in tissue morphogenesis and organogenesis during embryonic development. She has been studying the function and activity of the STAR family member Held Out Wing (HOW) in the fruit fly Drosophila since 1999. She served as the chair for the Society of Developmental Biology in Israel (ISDB). Dr. Volk has gained her BSc from Tel‑Aviv University, and her MSc and PhD degrees from the Weizmann Institute of Science, Rehovot, Israel. Karen Artzt is an Ashbel Smith Professor Emeritus at the University of Texas at Austin where she directed a research laboratory for 20 years. There she was a member of the Section of Molecular Genetics and Microbiology. Prior to that she was an associate Member of the Memorial Sloan Kettering Cancer Center in New York. Her main research interests include developmental genetics with an emphasis on cancer biology. In collaboration with Tom Ebersole she identified and cloned the mouse gene quaking that was one of the founding members of the STAR family. Dr. Artzt received her academic degrees from Cornell university; a BA from the Ithaca campus and a PhD from the Medical College School of Graduate Sciences in New York City. In 1972 she spent a year as a postdoctoral fellow at the Pasteur Institute in Paris under the direction of the Nobel Prize winner, Francois Jacob.

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