Abstract
Signal transduction and activation of RNA (STAR) family of RNA binding proteins are highly conserved through evolution indicating their core role during development, as well as in adult life. This chapter focuses on two Drosophila STAR proteins: Held Out Wing (HOW), the ortholog of mammalian Quaking (QKI) and Kep1, one of the four orthologs of mammalian Sam 68. I will emphasize the orthologs similarities in splicing pattern, functions and mode of actions of the two proteins relying on recent and earlier findings in the field. I will start with general description of the STAR proteins in Drosophila with an emphasis on their specific expression patterns.
Post-Transcriptional Regulation by STAR Proteins: Control of RNA Metabolism in Development and Disease, edited by Talila Volk and Karen Artzt.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gamberi C, Johnstone O, Lasko P. Drosophila RNA binding proteins. Int Rev Cytol 2006; 248:43–139.
Di Fruscio M et al. Kep1 interacts genetically with dredd/caspase-8 and kep1 mutants alter the balance of dredd isoforms. Proc Natl Acad Sci USA 2003; 100:1814–1819.
Ohno G, Hagiwara M, Kuroyanagi H. STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes Dev 2008; 22:360–374.
Nabel-Rosen H, Volohonsky G, Reuveny A et al. Two isoforms of the Drosophila RNA binding protein, how, act in opposing directions to regulate tendon cell differentiation. Dev Cell 2002; 2:183–193.
Nabel-Rosen H, Dorevitch N, Reuveny A et al. The balance between two isoforms of the Drosophila RNA-binding protein how controls tendon cell differentiation. Mol Cell 1999; 4:573–584.
Galarneau A, Richard S. Target RNA motif and target mRNAs of the Quaking STAR protein. Nat Struct Mol Biol 2005; 12:691–698.
Ryder SP, Frater LA, Abramovitz DL et al. RNA target specificity of the STAR/GSG domain post-transcriptional regulatory protein GLD-1. Nat Struct Mol Biol 2004; 11:20–28.
Israeli D, Nir R, Volk T. Dissection of the target specificity of the RNA-binding protein HOW reveals dpp mRNA as a novel HOW target. Development 2007; 134:2107–2114.
Zaffran S, Astier M, Gratecos D et al. The held out wings (how) Drosophila gene encodes a putative RNA-binding protein involved in the control of muscular and cardiac activity. Development 1997; 124:2087–2098.
Lo PC, Frasch M. A novel KH-domain protein mediates cell adhesion processes in Drosophila. Dev Biol 1997; 190:241–256.
Baehrecke EH. who encodes a KH RNA binding protein that functions in muscle development. Development 1997; 124:1323–1332.
Volk T. Singling out Drosophila tendon cells: a dialogue between two distinct cell types. Trends Genet 1999; 15:448–453.
Frommer G, Vorbruggen G, Pasca G et al. Epidermal egr-like zinc finger protein of Drosophila participates in myotube guidance. EMBO J 1996; 15:1642–1649.
Volohonsky G, Edenfeld G, Klambt C et al. Muscle-dependent maturation of tendon cells is induced by post-transcriptional regulation of stripeA. Development 2007; 134:347–356.
Yarnitzky T, Min L, Volk T. The Drosophila neuregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells. Genes Dev 1997; 11:2691–2700.
Volk T, Israeli D, Nir R et al. Tissue development and RNA control: “HOW” is it coordinated? Trends Genet 2008; 24:94–101.
Cox RD et al. Contrasting effects of ENU induced embryonic lethal mutations of the quaking gene. Genomics 1999; 57:333–341.
Chen Y, Tian D, Ku L et al. The selective RNA-binding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiation. J Biol Chem 2007; 282:23553–23560.
Hardy RJ. Molecular defects in the dysmyelinating mutant quaking. J Neurosci Res 1998; 51:417–422.
Furlong EE, Andersen EC, Null B et al. Patterns of gene expression during Drosophila mesoderm development. Science 2001; 293:1629–1633.
Nabel-Rosen H, Toledano-Katchalski H, Volohonsky G et al. Cell divisions in the drosophila embryonic mesoderm are repressed via post-transcriptional regulation of string/cdc25 by HOW. Curr Biol 2005; 15:295–302.
Toledano-Katchalski H, Nir R, Volohonsky G et al. Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Development 2007; 134:3473–3481.
Englund C, Birve A, Falileeva L et al. Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster. Dev Genes Evol 2006; 216:10–18.
Reuveny A, Elhanany H, Volk T. Enhanced sensitivity of midline glial cells to apoptosis is achieved by HOW(L)-dependent repression of Diap1. Mech Dev 2009; 126:30–41.
Stork T et al. Organization and function of the blood-brain barrier in Drosophila. J Neurosci 2008; 28:587–597.
Edenfeld G et al. The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in Drosophila. Neuron 2006; 52:969–980.
Bhat MA et al. Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron 2001; 30:369–383.
Stork T et al. Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper. Development 2009; 136:1251–1261.
Wu JI, Reed RB, Grabowski PJ et al. Function of quaking in myelination: regulation of alternative splicing. Proc Natl Acad Sci USA 2002; 99:4233–4238.
Medioni C, Astier M, Zmojdzian M et al. Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation. J Cell Biol 2008; 182:249–261.
Grosshans J, Wieschaus E. A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila. Cell 2000; 101:523–531.
Edgar BA, Lehman DA, O’Farrell PH. Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. Development 1994; 120:3131–3143.
Lehner CF. Pulling the string: cell cycle regulation during Drosophila development. Semin Cell Biol 1991; 2:223–231.
Xu D et al. Genetic control of programmed cell death (apoptosis) in Drosophila. Fly (Austin) 2009; 3:78–90.
Steller H. Regulation of apoptosis in Drosophila. Cell Death Differ 2008; 15:1132–1138.
Dotto GP, Silke J. More than cell death: caspases and caspase inhibitors on the move. Dev Cell 2004; 7:2–3.
Pilotte J, Larocque D, Richard S. Nuclear translocation controlled by alternatively spliced isoforms inactivates the QUAKING apoptotic inducer. Genes Dev 2001; 15:845–858.
Taylor SJ, Resnick RJ, Shalloway D. Sam68 exerts separable effects on cell cycle progression and apoptosis. BMC Cell Biol 5, 5 (2004).
Polotskaia A et al. Regulation of arginine methylation in endothelial cells: role in premature senescence and apoptosis. Cell Cycle 2007; 6:2524–2530.
Granderath S, Klambt C. Glia development in the embryonic CNS of Drosophila. Curr Opin Neurobiol 1999; 9:531–536.
Jacobs JR. The midline glia of Drosophila: a molecular genetic model for the developmental functions of glia. Prog Neurobiol 2000; 62:475–508.
Monk AC, Siddall NA, Volk T et al. HOW is required for stem cell maintenance in the Drosophila testis and for the onset of transit-amplifying divisions. Cell Stem Cell 2010; 6:348–360.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Landes Bioscience and Springer Science+Business Media
About this chapter
Cite this chapter
Volk, T. (2010). Drosophila STAR Proteins. In: Volk, T., Artzt, K. (eds) Post-Transcriptional Regulation by STAR Proteins. Advances in Experimental Medicine and Biology, vol 693. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7005-3_7
Download citation
DOI: https://doi.org/10.1007/978-1-4419-7005-3_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-7004-6
Online ISBN: 978-1-4419-7005-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)