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Star Trek

An Introduction to STAR Family Proteins and Review of Quaking (QKI)

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Post-Transcriptional Regulation by STAR Proteins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 693))

Abstract

The STAR family has an extremely diverse role during development and in RNA metabolism. We have concentrated on QKI as an example of this pleiotropic activity and also presented some new data on the role of its conserved 3-UTRs gleaned from bioinformatics analysis of theoretical miRNA binding sites. We review the concept of a direct pathway from signal transduction to activation of RNA, how this pathway could be the cell’s quick response to developmental and physiological changes and how it must be tightly regulated.

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Authors and Affiliations

  1. Department of Molecular Genetics and Microbiology Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, Texas, USA

    Karen Artzt

  2. Department of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA

    Jiang I. Wu

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  1. Karen Artzt
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  2. Jiang I. Wu
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Correspondence to Jiang I. Wu .

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Editors and Affiliations

  1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

    Talila Volk BSc, MSc, PhD

  2. Department of Molecular Genetics and Microbiology, Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, Texas, USA

    Karen Artzt BA, PhD

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Artzt, K., Wu, J.I. (2010). Star Trek. In: Volk, T., Artzt, K. (eds) Post-Transcriptional Regulation by STAR Proteins. Advances in Experimental Medicine and Biology, vol 693. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7005-3_1

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