Cerebral Cavernous Malformations (CCM)

Methods and Protocols

  • Lorenza Trabalzini
  • Federica Finetti
  • Saverio Francesco Retta

Part of the Methods in Molecular Biology book series (MIMB, volume 2152)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Overview of Cerebral Cavernous Malformations

    1. Front Matter
      Pages 1-1
    2. Saverio Francesco Retta, Andrea Perrelli, Lorenza Trabalzini, Federica Finetti
      Pages 3-25
    3. Giovanni G. Vercelli, Fabio Cofano, Filippo Veneziani Santonio, Francesca Vincitorio, Francesco Zenga, Diego Garbossa
      Pages 35-46
  3. Diagnosis and Treatment of Cerebral Cavernous Malformations

    1. Front Matter
      Pages 47-47
    2. Elisabeth Tournier-Lasserve
      Pages 49-57
    3. Valerio Benedetti, Elisa Pellegrino, Alfredo Brusco, Roberto Piva, Saverio Francesco Retta
      Pages 59-75
    4. Alessandra Splendiani, Federico Bruno, Alfonso Cerase
      Pages 97-107
    5. Marco M. Fontanella, Luca Zanin, Alessandro Fiorindi, Giannantonio Spena, Federico Nicolosi, Francesco Belotti et al.
      Pages 109-128
  4. Animal and Cellular Models of Cerebral Cavernous Malformations

    1. Front Matter
      Pages 129-129
    2. Simona Delle Monache, Saverio Francesco Retta
      Pages 131-137
    3. Preston Hale, Shady Ibrahim Soliman, Hao Sun, Miguel Alejandro Lopez-Ramirez
      Pages 139-150
    4. Luca Goitre, Claudia Fornelli, Alessia Zotta, Andrea Perrelli, Saverio Francesco Retta
      Pages 151-167
    5. Konrad Schwefel, Stefanie Spiegler, Christiane D. Much, Ute Felbor, Matthias Rath
      Pages 169-177
    6. Evelyn Popiel, William Brent Derry
      Pages 191-205
    7. Nicholas Nobiletti, Angela J. Glading
      Pages 259-265
  5. Cellular and Molecular Mechanisms of Cerebral Cavernous Malformations

    1. Front Matter
      Pages 267-267
    2. Ilya G. Serebriiskii, Mohamed Elmekawy, Erica A. Golemis
      Pages 269-289
    3. Oriana S. Fisher, Xiaofeng Li, Weizhi Liu, Rong Zhang, Titus J. Boggon
      Pages 291-302
    4. Johnathan Abou-Fadel, Jun Zhang
      Pages 303-310
    5. Simona Delle Monache, Saverio Francesco Retta
      Pages 371-375
    6. Saverio Marchi, Saverio Francesco Retta, Paolo Pinton
      Pages 417-426
    7. Juan Zalvide, Cristina Almengló, Sara Vázquez, Mar García-Colomer, Miriam Sartages, Celia M. Pombo
      Pages 437-443
    8. Cinzia Antognelli, Vincenzo Nicola Talesa, Saverio Francesco Retta
      Pages 445-449
  6. Back Matter
    Pages 487-496

About this book


This volume provides experimental approaches aimed to characterize the Cerebral Cavernous Malformations (CCM) disease and to define the cellular and molecular mechanisms underlying this pathology. Chapters are divided into four sections providing a general overview of the natural history, epidemiology, and pathogenetic mechanisms of CCM disease, describing methods currently used for diagnosis and treatment, production and analysis of distinct cellular and animal models in which CCM can be studied, and different methodological approaches to study the mechanisms underlying the CCM onset and progression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Cerebral Cavernous Malformations (CCM): Methods and Protocols  aims to ensure successful results in the further study of this complex disease and its pathophysiologic correlates.


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Editors and affiliations

  • Lorenza Trabalzini
    • 1
  • Federica Finetti
    • 2
  • Saverio Francesco Retta
    • 3
  1. 1.Department of Biotechnology, Chemistry and PharmacyUniversity of SienaSIENAItaly
  2. 2.Department of Biotechnology, Chemistry and PharmacyUniversity of SienaSIENAItaly
  3. 3.Department of Clinical and Biological Sciences, School of Medicine and SurgeryUniversity of TorinoORBASSANO (TORINO)Italy

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2020
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-0716-0639-1
  • Online ISBN 978-1-0716-0640-7
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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