Abstract
Cavernous cerebral malformations (CCMs) can show typical and characteristic findings at neuroradiology, above all at magnetic resonance imaging, but differential diagnosis with other lesions of similar appearance can be challenging and should be taken into consideration. Management of CCMs can be conservative in most cases, and thus appropriate follow-up timing and modality is required. Growing input from neurologists, neurosurgeons, neuroradiologists, and patients recommend to offer a standard neuroradiological report, to enhance interpretation and comparability in daily clinical practice. The purpose of this chapter is to present differential diagnosis, follow-up, and reporting of CCMs by neuroradiology.
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Labauge P, Brunereau L, Laberge S, Houtteville JP (2001) Prospective follow-up of 33 asymptomatic patients with familial cerebral cavernous malformations. Neurology 57:1825. https://doi.org/10.1212/WNL.57.10.1825
Labauge P, Brunereau L, Lévy C et al (2000) The natural history of familial cerebral cavernomas: a retrospective MRI study of 40 patients. Neuroradiology 42:327. https://doi.org/10.1007/s002340050893
Zabramski JM, Wascher TM, Spetzler RF et al (1994) The natural history of familial cavernous malformations: results of an ongoing study. J Neurosurg 80:422. https://doi.org/10.3171/jns.1994.80.3.0422
Campbell PG, Jabbour P, Yadla S, Awad IA (2010) Emerging clinical imaging techniques for cerebral cavernous malformations: a systematic review. Neurosurg Focus 29:E6. https://doi.org/10.3171/2010.5.FOCUS10120
Rigamonti D, Johnson PC, Spetzler RF et al (1991) Cavernous malformations and capillary telangiectasia: a spectrum within a single pathological entity. Neurosurgery 28:60. https://doi.org/10.1227/00006123-199101000-00010
Rigamonti D, Drayer BP, Johnson PC, Hadley MN, Zabramski J, Spetzler RF (1987) The MRI appearance of cavernous malformations (angiomas). J Neurosurg 67:518–524
Golden M, Saeidi S, Liem B et al (2015) Sensitivity of patients with familial cerebral cavernous malformations to therapeutic radiation. J Med Imaging Radiat Oncol 59:134. https://doi.org/10.1111/1754-9485.12269
Dalyai RT, Ghobrial G, Awad I et al (2011) Management of incidental cavernous malformations: a review. Neurosurg Focus 31:E5. https://doi.org/10.3171/2011.9.FOCUS11211
Akers A, Al-Shahi Salman R, Awad IA et al (2017) Synopsis of guidelines for the clinical management of cerebral cavernous malformations: consensus recommendations based on systematic literature review by the angioma alliance scientific advisory board clinical experts panel. Clin Neurosurg 80:665. https://doi.org/10.1093/neuros/nyx091
Kivelev J, Niemelä M, Kivisaari R et al (2009) Long-term outcome of patients with multiple cerebral cavernous malformations. Neurosurgery 65:450. https://doi.org/10.1227/01.NEU.0000346269.59554.DB
Velz J, Stienen MN, Neidert MC et al (2018) Routinely performed serial follow-up imaging in asymptomatic patients with multiple cerebral cavernous malformations has no influence on surgical decision making. Front Neurol 9:848. https://doi.org/10.3389/fneur.2018.00848
Bulut HT, Sarica MA, Baykan AH (2014) The value of susceptibility weighted magnetic resonance imaging in evaluation of patients with familial cerebral cavernous angioma. Int J Clin Exp Med 7:5296–5302
Singla A, O’Neill JEB, Smith E, Scott RM (2013) Cavernous malformations of the brain after treatment for acute lymphocytic leukemia: presentation and long-term follow-up: clinical article. J Neurosurg Pediatr 11:127. https://doi.org/10.3171/2012.11.PEDS12235
Faraci M, Morana G, Bagnasco F et al (2011) Magnetic resonance imaging in childhood leukemia survivors treated with cranial radiotherapy: a cross sectional, single center study. Pediatr Blood Cancer 57:240. https://doi.org/10.1002/pbc.22923
Neu MA, Tanyildizi Y, Wingerter A et al (2018) Susceptibility-weighted magnetic resonance imaging of cerebrovascular sequelae after radiotherapy for pediatric brain tumors. Radiother Oncol 127:280. https://doi.org/10.1016/j.radonc.2018.03.010
Hemphill JC 3rd, Greenberg SM, Anderson CS et al (2015) Guidelines for the management of spontaneous intracerebral hemorrhage: a Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke 46:2032. https://doi.org/10.1161/STR.0000000000000069
Al-Shahi Salman RA, Berg MJ, Morrison L, Salman A (2008) Hemorrhage from cavernous malformations of the brain. Definition and reporting standards. Stroke 39:3222. https://doi.org/10.1161/STROKEAHA.108.515544
Cerase A, Franceschini R, Battistini S, Maria Vallone I, Penco S, Venturi C (2010) Cavernous malformation of the optic nerve mimicking optic neuritis. J Neuroophthalmol 30:126. https://doi.org/10.1097/WNO.0b013e3181ceb428
Muccio CF, Catapano G, Di Blasi A, Esposito G, Cerase A (2008) Giant cystic intraventricular cerebral cavernous malformation: MRI with pathologic correlation. A case report. Neuroradiol J 21:547–550
Rao G, Jensen RL (2003) Coexistent cerebral metastasis and cavernous malformation. J Neurol Neurosurg Psychiatry 74:105
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Splendiani, A., Bruno, F., Cerase, A. (2020). Neuroradiology: Differential Diagnosis, Follow-Up, and Reporting. In: Trabalzini, L., Finetti, F., Retta, S. (eds) Cerebral Cavernous Malformations (CCM) . Methods in Molecular Biology, vol 2152. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0640-7_8
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DOI: https://doi.org/10.1007/978-1-0716-0640-7_8
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