Overview
- Editors:
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Mauro Magnani
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University of Urbino, Urbino, Italy
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John R. DeLoach
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Agricultural Research Service Food Animal Protection Research Laboratory, United States Department of Agriculture, College Station, USA
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Table of contents (42 chapters)
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Resealed Erythrocytes as a Tool for Basic Studies
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- Victor M. Vitvitsky, Fazoil A. Ataullakhanov, Elena I. Sinauridze
Pages 149-156
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Resealed Erythrocytes as Cellular Bioreactors
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Front Matter
Pages 157-157
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- James L. Way, Elizabeth P. Cannon, Peter Leung, Ann Hawkins-Zitzer, Luqi Pei, Ilona Petrikovics
Pages 159-163
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- Paolino Ninfali, Luigia Rossi, Luciano Baronciani, Claude Ropars, Mauro Magnani
Pages 165-173
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- Roger Ktavtzoff, Isabelle Desbois, Christian Doinel, Philippe Colombat, Jean Pierre Lamagnere, Maurice Chassaigne et al.
Pages 175-182
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- Luigia Rossi, Marzia Bianchi, Alessandra Fraternale, Mauro Magnani
Pages 183-188
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- Mauro Magnani, Umberto Mancini, Marzia Bianchi, Antonio Fazi
Pages 189-194
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- Antonio Fazi, Umberto Mancini, Elena Piatti, Augusto Accorsi, Mauro Magnani
Pages 195-201
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- Elena I. Sinauridze, Victor M. Vitvitsky, Alexey V. Pichugin, Anatoly M. Zhabotinsky, Fazoil I. Ataullakhanov
Pages 203-206
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Resealed Erythrocytes as Advanced Drug Delivery Systems
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Front Matter
Pages 207-207
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- Fazoil I. Ataullakhanov, Victor M. Vitvitsky, Violetta L. Kovaleva, Svetlana B. Mironova
Pages 209-213
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- Sophie Noël-Hocquet, Said Jabbouri, Said Lazar, Jean Claude Maunier, Gerald Guillaumet, Claude Ropars
Pages 215-221
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- Michela Tonetti, Anna Gasparini, Marco Giovine, Umberto Benatti, Antonio De Flora
Pages 223-232
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- Costantino Salerno, Andrea Lucano, Carlo Crifò
Pages 233-238
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- Mauro Magnani, Luigia Rossi, Anna Casabianca, Alessandra Fraternale, Giuditta Schiavano, Giorgio Brandi et al.
Pages 239-245
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- Edoardo Beretta, Gian Italo Bischi, Fortunata Solimano
Pages 247-253
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Site Specific Targeting of Resealed Erythrocytes
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Front Matter
Pages 255-255
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- Laura Chiarantini, Robert Droleskey, Mauro Magnani, Heinz Kirch, John R. DeLoach
Pages 257-267
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- Laura Chiarantini, Robert E. Droleskey, John R. DeLoach
Pages 269-277
About this book
Until recently the only biomedical use of erythrocytes was in transfusion medicine to restore a normal oxygen delivery. The development of a technology that permits one to open and reseal erythrocytes has dramatically changed this perspective. Currently, a number of teams have shown that engineered erythrocytes can behave as circulating bioreactors for the degradation of toxic metabolites or the inactivation of xenobiotics, as drug delivery systems, as carriers of antigens of vaccinal interest, and in many others biomedical applications. The technology of opening and resealing the erythrocytes has also been used successfully to investigate several basic aspects of erythrocyte metabolism, survival, pathology, etc. Thus, researchers in this field have an extraordinary opportunity to specifically modify the erythrocytes by the introduction of enzymes that generate new metabolic abilities, antibodies that inactivate single metabolic steps, or metabolites that can influence oxygen delivery and/or other cell properties. Furthermore, the pharmacokinetics of any drug can be potentially manipulated by using the erythrocytes as a delivery system. This book, The Use of Resealed Erythrocytes, is based on the fourth meeting of the "International Society for the Use of Resealed Erythrocytes as Carriers and Bioreactors" (I. S. U. R. E. ), held in Urbino, Italy, in 1991, and examines the most recent applications and developments of this technology.
Editors and Affiliations
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University of Urbino, Urbino, Italy
Mauro Magnani
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Agricultural Research Service Food Animal Protection Research Laboratory, United States Department of Agriculture, College Station, USA
John R. DeLoach