Abstract
The treatment and therapy of many acute and chronic illnesses have largely involved the administration of drugs via the standard delivery systems, e.g. oral, parenteral, intra-muscular, and intravenous administration. These methods of administering a drug usually result in an immediate bio-availability of the drug. Anti-tumor agents require a high concentration to achieve a therapeutically relevant dose in the tumor cells. However, the amount of the drug required usually proves to be toxic to normal tissue. The need for an effective drug delivery system is underscored by the constraints associated with the collateral effects of using drugs at high doses. Many approaches to the problem of controlled and targeted drug delivery such as a polymeric sustained release system, liposomal drug carriers, and antibody drug carriers have been proposed and utilized during the last decade.1
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Chiarantini, L., Droleskey, R., Magnani, M., Kirch, H., DeLoach, J.R. (1992). Targeting of Eythrocytes to Cytotoxic T-Cells. In: Magnani, M., DeLoach, J.R. (eds) The Use of Resealed Erythrocytes as Carriers and Bioreactors. Advances in Experimental Medicine and Biology, vol 326. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3030-5_32
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DOI: https://doi.org/10.1007/978-1-4615-3030-5_32
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