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Prions

Food and Drug Safety

  • Conference proceedings
  • © 2005

Overview

Editors:
  1. Tetsuyuki Kitamoto

    1. Department of Prion Research, Tohoku University School of Medicine, Sendai, Japan

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  • Provide cutting edge topics of prion researches, allowing readers to understand state of the art

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Table of contents (61 papers)

  1. Comparative analyses of three mouse-adapted scrapie strains G1, Obihiro, and I3/I5 and pathogenesis of G1 strain-induced polyuria in ICR mice

    • Motohiro Horiuchi, Yu-koh Tamura, Hidefumi Furuoka
    Pages 185-186

  2. Dose effect on detection of PrPSc in follicular dendritic cells of knock-in mice for rapid bioassay

    • Shirou Mohri, Masahiro Asano, Yukiko Ishikawa, Yuichi Matsuura, Yukitoki Fujita, Tetsuyuki Kitamoto
    Pages 187-187

  3. Cell surface retention of PrPC by anti-PrP antibody prevents protease-resistant PrP formation

    • Motohiro Horiuchi, Chan-Lan Kim, Michiko Ogino, Hidefumi Furuoka, Morikazu Shinagawa
    Pages 189-190

  4. Prion-conformation-specific human antibodies established from phage display library

    • Shuhei Hashiguchi, Mayumi Yamamoto, Syoh Kitamoto, Toshihiro Nakashima, Hitoki Yamanaka, Daisuke Ishibashi et al.
    Pages 191-191

  5. Partial characterization of monoclonal antibodies which bind to disease-associated prion protein in immunoprecipitaion assay

    • Yuko K. Ushiki, Ryo Endo, Yoshihisa Shimizu, Yoshifumi Iwamaru, Takuji Yamamoto, Shunji Hattori et al.
    Pages 193-194

  6. Production and Characterization of Monoclonal Antibodies Specific for Prion Protein

    • Masanori Morita, Akimasa Ohmizu, Hideki Maeno, Takato Matsuo, Yoichi Ogata, Mitsuru Naiki et al.
    Pages 195-196

  7. In vitro selection of anti-mouse prion protein RNA aptamers

    • Satoru Sekiya, Ken Noda, Penmetcha K. R. Kumar, Takashi Yokoyama, Satoshi Nishikawa
    Pages 197-198

  8. Detection of the Prion Protein in a Liquid Phase Capture Assay Using Magnetic Beads Coupled to Protein A

    • Wen-Chu Yang, Edward S. Yeung, Mary Jo Schmerr, Walter Bodemer
    Pages 199-200

  9. New pretreatment method for immunohistochemistry for abnormal prion protein

    • Kensuke Sasaki, Katsumi Doh-ura, Toru Iwaki
    Pages 201-201

  10. Cellular prion protein suppresses the apoptosis in a neuronal cell line established from type-1 prion protein gene-deficient mice

    • Keiichi Saeki, Takuya Nishimura, Akikazu Sakudo, Yoshitsugu Matsumoto, Takashi Onodera
    Pages 203-203

  11. Cellular prion protein suppressess the apoptotic cell death by mediating the intracellular H2O2 in primary culture and immortalized neuronal cells

    • Izuru Nakamura, Takuya Nishimura, Keiichi Saeki, Yoshitsugu Matsumoto, Takashi Onodera
    Pages 205-205

  12. Targeting of cytosolic PrPC via a novel 14-3-3-Tom 70-mitochondrial BCL-2 pathway induces mitochondrial apoptosis

    • Naomi S. Hachiya, Makiko Yamada, Kota Watanabe, Akiko Jozuka, Yoshimichi Kozuka, Yuji Sakasegawa et al.
    Pages 207-208

  13. Microtubule-dependent intracellular trafficking of cellular prion protein

    • Naomi S. Hachiya, Kota Watanabe, Makiko Yamada, Yuji Sakasegawa, Kiyotoshi Kaneko
    Pages 209-209

  14. Hsp90 modifies the conformation of recombinant mouse prion protein in vitro

    • Yuji Sakasegawa, Naomi S. Hachiya, Kiyotoshi Kaneko
    Pages 211-211

  15. Purification and characterization of a novel ATP-dependent robust protein-unfoldase, Unfoldin

    • Naomi S. Hachiya, Makiko Yamada, Akiko Jozuka, Yoshimichi Kozuka, Yuji Sakasegawa, Kiyotoshi Kaneko
    Pages 213-213

  16. Nucleic acid and Prion protein interaction produces spherical amyloids which in vivo can function as coats of Spongiform Encephalopathy agent

    • P. K. Nandi, J -C. Nicole
    Pages 215-215

  17. Species barrier in yeast [PSI+] prion transmission

    • Hideyuki Hara, Toru Nakayashiki, Yoshikazu Nakamura
    Pages 217-217

  18. Molecular memory of [PSI+] prion strains in S. cerevisiae is dependent on the primary structure of the Sup35 prion domain

    • Colin G. Crist, Toru Nakayashiki, Hiroshi Kurahashi, Yoshikazu Nakamura
    Pages 219-220

  19. Expression of a splice variant of prion protein during hypoxia in human glioblastoma cell line T98G

    • Yutaka Kikuchi, Tomoshi Kakeya, Ayako Sakai, Haruo Matsuda, Takeshi Yamazaki, Ken-ichi Tanamoto et al.
    Pages 221-221

  20. PRNP promoter region polymorphism in Creutzfeldt-Jakob disease

    • Pawel P. Liberski, Jolanta Bratosiewicz-WÄ…sik J, Anna ZieliÅ„ska, Gerard H. Jansen, Tomasz J. WÄ…sik
    Pages 223-224
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Keywords

About this book

Prion diseases recently have attracted interest not only scientifically but also socially because of the bovine spongiform encephalopathy (BSE) epidemic and the outbreak of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom. In 2004, the International Symposium of Prion Diseases for Food and Drug Safety was held October 31–November 2 in Sendai, Japan, where, 20 years earlier, arguments were first heard on whether the etiologic agent of transmissible spongiform encephalopathy was prions or scrapie-associated fibrils. This volume is a collection of current work on prion research that was presented at the 2004 symposium. Topics included range from basic research to clinical aspects of prion diseases, making the book a valuable resource for researchers and clinicians, and encouraging further developments by the next generation of researchers.

Editors and Affiliations

  • Department of Prion Research, Tohoku University School of Medicine, Sendai, Japan

    Tetsuyuki Kitamoto

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