Abstract
Conformational conversion of cellular prion protein (PrPC) to scrapie-form prion protein (PrPSc) is thought to be the central event in prion pathogenesis. Several studies have shown that their distinct conformation should cause different immunogenic properties, however, almost all mAbs generated against PrP are unable to recognize each ones separately. Such characters of mAbs make it diffcult to study conformational difference between PrPC and PrPSc or mechanism of prion replication. Therefore the purpose of this study is to generate such mAbs that would react with PrPSc but not with PrPC.
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© 2005 Springer-Verlag Tokyo
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Ushiki, Y.K. et al. (2005). Partial characterization of monoclonal antibodies which bind to disease-associated prion protein in immunoprecipitaion assay. In: Kitamoto, T. (eds) Prions. Springer, Tokyo. https://doi.org/10.1007/4-431-29402-3_24
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DOI: https://doi.org/10.1007/4-431-29402-3_24
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-25539-0
Online ISBN: 978-4-431-29402-3
eBook Packages: MedicineMedicine (R0)