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Production and Characterization of Monoclonal Antibodies Specific for Prion Protein

  • Conference paper
Prions

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Abstract

Creutzfeldt-Jacob disease (CJD) is a neurodegenerative disorder caused by piron, which mainly consists of abnormal prion protein (PrPSc). As PrPSc was detected recently in two patients who received transfusion from preclinical variant CJD (vCJD), concerns about the theoretical risk of transmission of vCJD through blood products increased. In order to contribute the blood products-safety against prion, we aimed at obtaining monoclonal antibodies (mAbs) eligible for screening procedures.

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Authors and Affiliations

  1. Committee on Creutzfeldt-Jacob disease, Japanese Ketsueki-Seizai (Blood Products) Association, Japan

    Masanori Morita, Akimasa Ohmizu, Hideki Maeno, Takato Matsuo, Yoichi Ogata, Mitsuru Naiki, Shouji Suzuki & Isao Nakata

  2. Benesis Corp., 2-1 Seiryo, Aoba-ku, Sendai, 980-8575, Japan

    Masanori Morita & Akimasa Ohmizu

  3. Japanese Red Cross Plasma Fractionation Center, Japan

    Hideki Maeno

  4. Nihon Pharmaceutical Co. Ltd., Japan

    Takato Matsuo

  5. The Chemo-Sero-Therapeutic Research Institute, Japan

    Yoichi Ogata

  6. Nippon Zoki Pharmaceutical Co. Ltd., Japan

    Mitsuru Naiki, Shouji Suzuki & Isao Nakata

Authors
  1. Masanori Morita
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  2. Akimasa Ohmizu
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  3. Hideki Maeno
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  4. Takato Matsuo
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  5. Yoichi Ogata
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  6. Mitsuru Naiki
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  7. Shouji Suzuki
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  8. Isao Nakata
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Editor information

Editors and Affiliations

  1. Department of Prion Research, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Tetsuyuki Kitamoto M.D.

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© 2005 Springer-Verlag Tokyo

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Cite this paper

Morita, M. et al. (2005). Production and Characterization of Monoclonal Antibodies Specific for Prion Protein. In: Kitamoto, T. (eds) Prions. Springer, Tokyo. https://doi.org/10.1007/4-431-29402-3_25

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  • DOI: https://doi.org/10.1007/4-431-29402-3_25

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-25539-0

  • Online ISBN: 978-4-431-29402-3

  • eBook Packages: MedicineMedicine (R0)

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