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Neurohumoral and Autonomic Regulation of Blood Pressure

Pediatric Hypertension

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Abstract

Interacting neural, hormonal, and metabolic mechanisms act locally and systemically to regulate cardiovascular function. This chapter discusses the basic physiological mechanisms of the neurohumoral and autonomic contributions to blood pressure regulation. Much that we will present about these mechanisms stems from studies in experimental animal models. Differential rates of maturation of these systems affect their ability to maintain blood pressure and delivery of oxygen and nutrients at specific times of life. This chapter outlines autonomic control of the fetal and postnatal cardiovascular system, particularly highlighting developmental changes in arterial baroreflex, cardiopulmonary reflex, and chemoreflex function. Additionally, humoral factors that act within the central and peripheral nervous system to influence sympathovagal balance will be discussed.

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Authors and Affiliations

  1. Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA

    Jeffrey L. Segar

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  1. Jeffrey L. Segar
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Correspondence to Jeffrey L. Segar .

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Editors and Affiliations

  1. Division of Nephrology, Seattle Children's Hospital, Seattle, Washington, USA

    Joseph Flynn

  2. Massachusetts General Hospital, Boston, Massachusetts, USA

    Julie R. Ingelfinger

  3. Arkansas Children's Hospital, University of Arkansas Medical Science, Little Rock, Arkansas, USA

    Karen Redwine

Section Editor information

  1. Pediatric Nephrology Unit, MassGeneral Hospital for Children at MGH, Harvard Medical School, Fruit St. 55, 02114, Boston, MA, USA

    Julie R. Ingelfinger M.D.

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Segar, J.L. (2017). Neurohumoral and Autonomic Regulation of Blood Pressure. In: Flynn, J., Ingelfinger, J., Redwine, K. (eds) Pediatric Hypertension. Springer, Cham. https://doi.org/10.1007/978-3-319-31420-4_1-1

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  • DOI: https://doi.org/10.1007/978-3-319-31420-4_1-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31420-4

  • Online ISBN: 978-3-319-31420-4

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  1. Latest

    Neurohumoral and Autonomic Regulation of Blood Pressure
    Published:
    03 August 2022

    DOI: https://doi.org/10.1007/978-3-319-31420-4_1-2

  2. Original

    Neurohumoral and Autonomic Regulation of Blood Pressure
    Published:
    03 March 2017

    DOI: https://doi.org/10.1007/978-3-319-31420-4_1-1

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