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Role of Clostridium perfringens Alpha, Beta, Epsilon, and Iota Toxins in Enterotoxemia of Monogastrics and Ruminants

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Microbial Toxins

Part of the book series: Toxinology ((TOXI))

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Abstract

Clostridium perfringens produce several virulence factors to increase colonization and improve nutrient availability. Enterotoxins are among these virulence factors, and while some only have local effects, others can act at a distance from the bacterial colonization site. Enterotoxemias are defined as diseases caused by toxins generated in the intestine and absorbed into systemic circulation with systemic consequences. The term enterotoxemia is generally used indistinctly to name enteric and/or systemic diseases, but under the definition of enterotoxemia, several aspects of intestinal bacterial diseases include pathogenesis and toxin modes of action. The present aim is to describe some enterotoxemia-associated toxins, focusing on those which clearly produce systemic and enteric effects, as well as those commonly thought to produce enterotoxemia but remain questionable upon further consideration of the existing evidence.

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Authors and Affiliations

  1. Instituto de Patobiologia - Centro de Investigación en Ciencias Veterinarias y Agronómicas, Instituto Nacional de Tecnología Agropecuaria, Calle Las Cabañas y Los Reseros s/n, Casilla de Correo 25 (1712), Castelar, Buenos Aires, Argentina

    Mariano E. Fernandez-Miyakawa & Leandro M. Redondo

  2. Consejo Nacional de Investigaciones Científicas y Técnicas, Rivadavia 1917 (1033), Ciudad Autónoma de Buenos Aires, Argentina

    Mariano E. Fernandez-Miyakawa & Leandro M. Redondo

Authors
  1. Mariano E. Fernandez-Miyakawa
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  2. Leandro M. Redondo
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Corresponding authors

Correspondence to Mariano E. Fernandez-Miyakawa or Leandro M. Redondo .

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Editors and Affiliations

  1. Biology Department, Wilson College, Chambersburg, Pennsylvania, USA

    Brad Stiles

  2. Department of Biochemistry, School of Medicine and Instituto Clodomiro Picado, Faculty of Microbiology, University of Costa Rica, San Pedro de Montes de Oca, Costa Rica

    Alberto Alape-Girón

  3. Department of Pathology and Microbiology, Université de Montréal, Saint-Hyacinthe, Québec, Canada

    J. Daniel Dubreuil

  4. College of Pharmacy, Roseman University of Health Sciences, Henderson, Nevada, USA

    Manas Mandal

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Fernandez-Miyakawa, M.E., Redondo, L.M. (2018). Role of Clostridium perfringens Alpha, Beta, Epsilon, and Iota Toxins in Enterotoxemia of Monogastrics and Ruminants. In: Stiles, B., Alape-Girón, A., Dubreuil, J., Mandal, M. (eds) Microbial Toxins. Toxinology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6449-1_16

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