Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Bacillus Toxins

    1. Front Matter
      Pages 1-1
    2. Yannick Trescos, Clémence Rougeaux, Jean-Nicolas Tournier
      Pages 3-14
    3. Mario Soberón, Rose Monnerat, Alejandra Bravo
      Pages 15-27
  3. Burkholderia Toxins

    1. Front Matter
      Pages 29-29
    2. Ramar Perumal Samy, Gautam Sethi, Bradley G. Stiles, Sok Lin Foo, Octavio Luiz Franco, Frank Arfuso et al.
      Pages 31-49
  4. Clostridium Toxins

    1. Front Matter
      Pages 51-51
    2. Michel R. Popoff, Bradley G. Stiles, Bernard Poulain
      Pages 53-72
    3. Bradley G. Stiles, Holger Barth, Michel R. Popoff
      Pages 73-92
    4. M. Flores-Díaz, E. Barquero-Calvo, M. Ramírez, A. Alape-Girón
      Pages 119-134
    5. Joseph W. Alvin, D. Borden Lacy
      Pages 135-152
    6. Diana López-Ureña, Carlos Quesada-Gómez, César Rodríguez, Esteban Chaves-Olarte
      Pages 153-170
    7. Ornella Rossetto, Cesare Montecucco
      Pages 171-186
  5. Escherichia Toxins

    1. Front Matter
      Pages 187-187
    2. Samuel M. Chekabab, Josée Harel
      Pages 189-203
  6. Helicobacter Toxins

    1. Front Matter
      Pages 245-245

About this book

Introduction

This volume provides an overview of microbial toxins from diverse bacterial and fungal origins. These molecules, produced by various species and consisting of protein or small organic molecules, can play a pivotal role in pathogenesis of plants, animals, and humans that in turn can lead to the survival/dissemination of the host microbe. Many of these microbes, due to their toxins, impact our society from a health and economic perspective. In particular, this volume address the diverse niches of these organisms focused upon their associated toxins. The structures, functions, and genetics of toxins will be addressed. Besides the ill-effects elicited by these toxins, it must be noted that there is immense potential for turning some of these harmful molecules into useful tools as specific probes (of receptors), novel drugs or drug-conjugates for the treatment of various diseases, and immunomodulating agents for targeted vaccine delivery for research and unique medicines. Recent progress in bacterial genome mapping and establishment of three-dimensional crystal structures of several bacterial toxins provides a deeper knowledge and greater understanding of structure-function relationships. Moreover, the emergence of some bacteria (i.e., Bacillus anthracisBurkholderia pseudomalleiStaphylococcus aureus), and their toxins, as biological weapons also necessitates a thorough understanding of these agents, their pathophysiology, and development of countermeasures. This volume will also be a common resource for researchers interested in many other medically-relevant microorganisms, and their toxins, that include Clostridium botulinum, C. difficile, C. perfringens, C. tetani, Escherichia coli, Helicobacter pylori, and Listeria monocytogenes. Recent studies have correlated the effect of global warming and climate change as a trigger for natural disasters and impact on human health via emergence of various vector-borne and infectious diseases caused by toxin-producing microbes. The 2003 Institute of Medicine (IOM) report, “Microbial Threats to Health,” identified the influence of changing ecosystem on the emergence and spread of infectious diseases and economic development of specific regions of the world. This current handbook is a major reference work on microbial toxins written by a panel of International experts and organized into 24 chapters.

Keywords

Drug Development Drug Discovery Toxin Toxinology Venom

Editors and affiliations

  • P. Gopalakrishnakone (Editor-in-Chief)
    • 1
  • Brad Stiles
    • 2
  • Alberto Alape-Girón
    • 3
  • J. Daniel Dubreuil
    • 4
  • Manas Mandal
    • 5
  1. 1.Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore
  2. 2.Biology DepartmentWilson CollegeChambersburgUSA
  3. 3.Department of Biochemistry, School of Medicine and Instituto Clodomiro Picado, Faculty of MicrobiologyUniversity of Costa RicaSan Pedro de Montes de OcaCosta Rica
  4. 4.Department of Pathology and MicrobiologyUniversité de MontréalSaint-HyacintheCanada
  5. 5.College of PharmacyRoseman University of Health SciencesHendersonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-6449-1
  • Copyright Information Springer Science+Business Media B.V. 2018
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-6448-4
  • Online ISBN 978-94-007-6449-1
  • Series Print ISSN 2542-761X
  • Series Online ISSN 2542-7644
  • About this book
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