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Autosomal dominante polyzystische Nierenerkrankung (ADPKD)

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DGIM Innere Medizin

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Zusammenfassung

Die autosomal dominante polyzystische Nierenerkrankung (ADPKD) ist die häufigste hereditäre Nierenerkrankung. Sie ist durch langsames, kontinuierliches Zystenwachstum beider Nieren charakterisiert. Zentrale Folge ist der Verlust der Nierenfunktion und die Notwendigkeit einer Nierenersatztherapie, welche im Mittel in der 6. Lebensdekade erreicht wird. Zusätzlich ist die ADPKD durch zahlreiche extrarenale Manifestationen, sowie lokale Schmerzen und Beschwerden geprägt. Neben supportiven Maßnahmen ist seit 2015 mit Tolvaptan das erste zielgerichtete Medikament zugelassen, das den Verlust der Nierenfunktion verlangsamen, diesen aber ebenso wie die Zystenbildung nicht stoppen oder rückgängig machen kann.

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Authors and Affiliations

  1. Universität zu Köln, Medizinische Fakultät und Uniklinik Köln, Klinik II für Innere Medizin, Köln, Deutschland

    Sita Arjune, Sebastian Strubl & Roman-Ulrich Müller

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  1. Sita Arjune
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  2. Sebastian Strubl
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  3. Roman-Ulrich Müller
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Correspondence to Roman-Ulrich Müller .

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Editors and Affiliations

  1. Universität Salzburg, Salzburg, Österreich

    Hendrik Lehnert

  2. Innere Medizin IV, Helios Dr. Horst Schmidt Kliniken Wiesba, Wiesbaden, Deutschland

    Elisabeth Märker-Hermann

  3. Medizinische Klinik I, Universitätsklinikum Aachen, RWTH Aache, Aachen, Nordrhein-Westfalen, Deutschland

    Nikolaus Marx

  4. Institut für Endokrinologie & Diabetes, Universität zu Lübeck, Lübeck, Deutschland

    Sebastian M. Meyhöfer

Section Editor information

  1. Med. Klinik III (Nieren- und Hochdruckerkrankungen, Rheumatologie), Sana-Klinikum Offenbach GmbH, Offenbach, Deutschland

    Kirsten de Groot

  2. I. Medizinische Klinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Deutschland

    Julia Weinmann-Menke

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Arjune, S., Strubl, S., Müller, RU. (2024). Autosomal dominante polyzystische Nierenerkrankung (ADPKD). In: Lehnert, H., Märker-Hermann, E., Marx, N., Meyhöfer, S.M. (eds) DGIM Innere Medizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54676-1_63-2

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  1. Latest

    Autosomal dominante polyzystische Nierenerkrankung (ADPKD)
    Published:
    27 December 2023

    DOI: https://doi.org/10.1007/978-3-642-54676-1_63-2

  2. Original

    Autosomal dominante polyzystische Nierenerkrankung (ADPKD)
    Published:
    25 November 2014

    DOI: https://doi.org/10.1007/978-3-642-54676-1_63-1

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