Abstract
The hundred years of pharmaceutical research from 1880 to 1980 were punctuated by trial and error, but also by elegant ideas and their translation into therapeutically valuable principles. Many lead structures were found by accident (see Chap. 2, “In the Beginning, There Was Serendipity”), others came from traditional medicines or from biochemical concepts. In contrast to modern drug research, classical design was the result of rather limited knowledge of the pathophysiology and cellular and molecular etiology of disease, and was restricted to animal experiments. Nonetheless, this phase, and particularly the last 50 years, has been exceptionally successful. The targeted fight against infectious diseases and the successful treatment of many psychiatric and other important diseases can be attributed to this period in drug development. With this came a significant increase in quality of life and life expectancy. In the following sections, selected examples are used to demonstrate different aspects of classical pharmaceutical research.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Bibliography
General Literature
Burger A (1983) A guide to the chemical basis of drug design. Wiley, New York
Ryan J, Newman A, Jacobs M (eds) (2000) The pharmaceutical century. Ten decades of drug discovery. American Chemical Society, Washington, DC, Supplement to ACS Publications
Sneader W (1996) Drug prototypes and their exploitation. Wiley, Chichester
Sneader W (2005) Drug discovery. A history. Wiley, Chichester
Verg E (1988) Meilensteine: 125 Jahre Bayer, 1863–1988. Bayer AG, Leverkusen
Special Literature
Aspirin – eine unendliche Geschichte, Research. Das Bayer-Forschungsmagazin, Issue 6, S. 4–21 (1992) and other articles in this magazine
Battistini B, Botting R, Bakhle YS (1994) COX-1 and COX-2: toward the development of more selective NSAIDs. Drug News Perspect 7:501–512
Kelce WR et al (1995) Persistent DDT Metabolite p, p’-DDE is a potent androgen receptor antagonist. Nature 375:581–585
Patrono C (1989) Aspirin and human platelets: from clinical trials to acetylation of cyclooxygenase and back. Trends Pharm Sci 10:453–458
Schlitzer M (2007) Malaria chemotherapeutics part I: history of antimalarial drug development, currently used therapeutics, and drugs in clinical development. Chem Med Chem 2:944–986
Wiesner J, Ortmann R, Jomaa H, Schlitzer M (2003) New antimalarial drugs. Angew Chem Int Ed Engl 42:5274–5293
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Klebe, G. (2013). Classical Drug Research. In: Klebe, G. (eds) Drug Design. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17907-5_3
Download citation
DOI: https://doi.org/10.1007/978-3-642-17907-5_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-17906-8
Online ISBN: 978-3-642-17907-5
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences
