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Cerebro-Cerebellar Connections

Handbook of the Cerebellum and Cerebellar Disorders

  • 156 Accesses

Abstract

The cerebro-cerebellar system is one of the largest pathways in the central nervous system, yet knowledge of its structure and function remains far from complete. This is an important gap in understanding because anatomical connectivity is a key determinant of cerebellar function. This updated chapter focuses on recent advances in understanding the anatomical and physiological properties of cerebro-cerebellar connections in nonhuman species. There are two main routes by which cerebral information can gain access to the cerebellum: cerebro-pontocerebellar pathways that terminate in the cerebellar cortex as mossy fibers and cerebro-olivocerebellar pathways that terminate as climbing fibers. A common principle of organization seems to be the convergence of somatotopically corresponding pathways, with the climbing fiber system playing a key role in imposing this order. In addition to this well-ordered spatial arrangement, there is also precise timing of integration of ascending and descending inputs. The spatial and temporal congruence of inputs is consistent with the one-map hypothesis of cerebellar organization (Apps and Hawkes, Nat Rev Neurosci 10:670-681, 2009). The functional significance of this precise arrangement remains to be determined but is likely to have a major impact on cerebellar activity.

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Authors and Affiliations

  1. Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK

    Thomas C. Watson

  2. Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK

    Thomas C. Watson

  3. Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, UK

    Thomas C. Watson

  4. School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK

    Richard Apps

Authors
  1. Thomas C. Watson
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  2. Richard Apps
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Correspondence to Thomas C. Watson or Richard Apps .

Editor information

Editors and Affiliations

  1. Bruxelles, Belgium

    Mario Manto

  2. Scripps Research Institute Dept. Neuropharmacology, La Jolla, CA, USA

    Donna Gruol

  3. Dept. Neurology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA

    Jeremy Schmahmann

  4. Gunma University Dept. Integrative Physiology, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  5. Dept Pathology & Immunology & Neuro, Baylor College of Medicine Dept Pathology & Immunology & Neuro, Houston, TX, USA

    Roy Sillitoe

Section Editor information

  1. Molecular and Integrative Neuroscience Department (MIND), The Scripps Research Institute, La Jolla, California, USA

    Donna L. Gruol

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Watson, T.C., Apps, R. (2019). Cerebro-Cerebellar Connections. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_48-2

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  • DOI: https://doi.org/10.1007/978-3-319-97911-3_48-2

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  • Print ISBN: 978-3-319-97911-3

  • Online ISBN: 978-3-319-97911-3

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  1. Latest

    Cerebro-Cerebellar Connections
    Published:
    23 May 2019

    DOI: https://doi.org/10.1007/978-3-319-97911-3_48-3

  2. Original

    Cerebro-Cerebellar Connections
    Published:
    01 March 2019

    DOI: https://doi.org/10.1007/978-3-319-97911-3_48-2

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