Definition
The word sarcopenia originates from the Greek words sarx (muscle) and -penia (loss). Sarcopenia is a progressive and generalized skeletal muscle disorder that is associated with increased likelihood of adverse outcomes including falls, fractures, physical disability, and mortality.
Overview
Sarcopenia increases risk of falls and fractures, impairs ability to perform activities of daily living, leads to mobility disorders and loss of independence, impairs quality of life, and increases need for long-term care placement and death. It increases risk for hospitalization and the cost. It is observed more prevalent by aging, but many other factors contribute and increase risk of developing sarcopenia involving systemic diseases especially organ failures, inflammatory conditions, physical inactivity, nutritional deficiencies, and unhealthy food choices. Hence, sarcopenia may be associated with many prevalent diseases such as cardiac/respiratory/renal diseases, malignancies, and...
References
Anagnostis P, Dimopoulou C, Karras S et al (2015) Sarcopenia in post-menopausal women: is there any role for vitamin D? Maturitas 82(1):56–64
Bahat G, Tufan A, Kilic C et al (2018a) Prevalence of sarcopenia and its components in community-dwelling outpatient older adults and their relation with functionality. Aging Male 5:1–7. https://doi.org/10.1080/13685538.2018.1511976
Bahat G, Yilmaz O, Kılıç C et al (2018b) Performance of SARC-F in regard to sarcopenia definitions, muscle mass and functional measures. J Nutr Health Aging 22(8):898–903
Bahat G, Kilic C, Ilhan B et al (2019) Association of different bioimpedanciometry estimations of muscle mass with functional measures. Geriatr Gerontol Int (in press)
Baumgartner R, Koehler K, Gallagher D et al (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147:755–763
Beaudart C, Locquet M, Bornheim S et al (2018) French translation and validation of the sarcopenia screening tool SARC-F. Eur Geriatr Med 9:29. https://doi.org/10.1007/s41999-017-0007-1
Blackman MR, Sorkin JD, Munzer T et al (2002) Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA 288(18):2282–2292
Buckinx F, Landi F, Cesari M et al (2018) Pitfalls in the measurement of muscle mass: a need for a reference standard. J Cachexia Sarcopenia Muscle 9:269–278
Cawthon PM, Peters KW, Shardell MD et al (2014) Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. J Gerontol A Biol Sci Med Sci 69(5):567–575. https://doi.org/10.1093/gerona/glu023
Cawthon PM, Travison TG, Manini TM et al (2019) Sarcopenia definition and outcomes consortium conference participants. Establishing the link between lean mass and grip strength cut-points with mobility disability and other health outcomes: proceedings of the sarcopenia definition and outcomes consortium conference. J Gerontol A Biol Sci Med Sci 14:glz081. https://doi.org/10.1093/gerona/glz081
Critchley M (1931) The neurology of old age. Lancet 1:1221–1230
Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al (2010) European working group on sarcopenia in older people. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age Ageing 39(4):412–423. https://doi.org/10.1093/ageing/afq034.
Cruz-Jentoft AJ, Landi F, Schneider SM et al (2014) Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the international sarcopenia initiative (EWGSOP and IWGS). Age Ageing 43(6):748–759. https://doi.org/10.1093/ageing/afu115
Cruz-Jentoft AJ, Bahat G, Bauer J et al (2019) Writing Group for the European Working Group on sarcopenia in older people 2 (EWGSOP2), and the extended group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48(1):16–31. https://doi.org/10.1093/ageing/afy169
De Spiegeleer A, Beckwée D, Bautmans I et al (2018) Sarcopenia guidelines development group of the Belgian Society of Gerontology and Geriatrics (BSGG). Pharmacological interventions to improve muscle mass, muscle strength and physical performance in older people: an umbrella review of systematic reviews and meta-analyses. Drugs Aging 35(8):719–734. https://doi.org/10.1007/s40266-018-0566-y.
Dent E, Morley JE, Cruz-Jentoft AJ et al (2018) International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management. J Nutr Health Aging 22(10):1148–1161. https://doi.org/10.1007/s12603-018-1139-9
Fearon K, Strasser F, Anker SD et al (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12:489–495
Fielding RA, Vellas B, Evans WJ et al (2011) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 12:249–256
Garcia JM, Boccia RV, Graham CD et al (2015) Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials. Lancet Oncol 16(1):108–116
Hamaguchi Y, Kaido T, Okumura S et al (2017) Impact of skeletal muscle mass index, intramuscular adipose tissue content, and visceral to subcutaneous adipose tissue area ratio on early mortality of living donor liver transplantation. Transplantation 101(3):565–574
Heymsfield SB, Gonzalez MC, Lu J et al (2015) Skeletal muscle mass and quality: evolution of modern measurement concepts in the context of sarcopenia. Proc Nutr Soc 74:355–366
Ibrahim K, May C, Patel HP et al (2016) A feasibility study of implementing grip strength measurement into routine hospital practice (GRImP): study protocol. Pilot Feasibility Study 2:27
Ishii S, Tanaka T, Shibasaki K et al (2014) Development of a simple screening test for sarcopenia in older adults. Geriatr Gerontol Int. 2014 14(Suppl 1):93–101
Isidori AM, Giannetta E, Greco EA et al (2005) Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin Endocrinol 63(3):280–293
Janssen I, Heymsfield SB, Ross R (2002) Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50:889–896
Kim MJ, Morley JE (2005) The hormonal fountains of youth: myth or reality. J Endocrinol Investig 28(11 Suppl Proceedings):5–14
Kittiskulnam P, Carrero JJ, Chertow GM et al (2017) Sarcopenia among patients receiving hemodialysis: weighing the evidence. J Cachexia Sarcopenia Muscle 8(1):57–68. https://doi.org/10.1002/jcsm.12130
Leong DP, Teo KK, Rangarajan S et al (2015) Prognostic value of grip strength: findings from the prospective urban rural epidemiology (PURE) study. Lancet 386:266–273
Liu CJ, Latham NK (2009) Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst Rev (3):CD002759. https://doi.org/10.1002/14651858.CD002759
Masanes F, Rojano ILX, Salva A et al (2017) Cut-off points for muscle mass – not grip strength or gait speed – determine variations in sarcopenia prevalence. J Nutr Health Aging 21:825–829
McGregor RA, Cameron-Smith D, Poppitt SD (2014) It is not just muscle mass: a review of muscle quality, composition and metabolism during ageing as determinants of muscle function and mobility in later life. Longev Healthspan 3:9
Morley JE, Abbatecola AM, Argiles JM et al (2011) Society on sarcopenia, cachexia and wasting disorders trialist workshop. Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc 12(6):403–409. https://doi.org/10.1016/j.jamda.2011.04.014
Muscaritoli M, Anker SD, Argiles J et al (2010) Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”. Clin Nutr 29(2):154–159
Newman A, Kupelian V, Visser M et al (2003) Sarcopenia: alternative definitions and association with lower extremity function. J Am Geriatr Soc 51:1602–1609
Paddon-Jones D, Rasmussen BB (2009) Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care 12(1):86–90. https://doi.org/10.1097/MCO.0b013e32831cef8b
Rolland Y, Lauwers-Cances V, Pahor M et al (2004) Muscle strength in obese elderly women: effect of recreational physical activity in a cross-sectional study. Am J Clin Nutr 79:552–557
Rosenberg IH (1989) Summary comments: epidemiologic and methodologic problems in determining nutritional status of older persons. Am J Clin Nutr 50:1231–1233
Snyder P, Bhasin S, Cunningham G et al (2016) Effects of testosterone treatment in older men. N Engl J Med 374(7):611–624
Studenski SA, Peters KW, Alley DE et al (2014) The FNIH sarcopenia project: rationale and study description. J Gerontol A Biol Sci Med Sci 5:547–558
Sumukadas D, Witham MD, Struthers AD (2007) Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial. CMAJ 177:867–874
Trevino-Aguirre E, Lopez-Teros T, Gutierrez-Robledo L et al (2014) Availability and use of dual energy X-ray absorptiometry (DXA) and bio-impedance analysis (BIA) for the evaluation of sarcopenia by Belgian and Latin American geriatricians. J Cachexia Sarcopenia Muscle 5:79–81
Yamada Y, Nishizawa M, Uchiyama T et al (2017) Developing and validating an age-independent equation using multi-frequency bioelectrical impedance analysis for estimation of appendicular skeletal muscle mass and establishing a cutoff for sarcopenia. Int J Environ Res Public Health 14. https://doi.org/10.3390/ijerph14070809.
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Bahat, G., Erdoğan, T. (2020). Sarcopenia. In: Gu, D., Dupre, M. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham. https://doi.org/10.1007/978-3-319-69892-2_541-2
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DOI: https://doi.org/10.1007/978-3-319-69892-2_541-2
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Sarcopenia- Published:
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DOI: https://doi.org/10.1007/978-3-319-69892-2_541-3
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DOI: https://doi.org/10.1007/978-3-319-69892-2_541-1