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Atopic Dermatitis Outcome Measures

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Cutaneous Biometrics

Abstract

The validation and standardization of outcome measures for atopic dermatitis (AD) have advanced significantly in the last decade, predominantly led by the Harmonizing Outcome Measures for Eczema (HOME) initiative. Clinical signs, symptoms, quality of life, and long-term control have been defined by the HOME group as the core outcome domains to be used as primary or secondary endpoints for atopic dermatitis trials. The Eczema Area and Severity Index (EASI) score was chosen as the core measure for the clinical signs domain, among at least 13 other measures of clinical signs. The Patient-Oriented Eczema Measure (POEM) score was chosen the core measure for the symptoms domain, among at least 12 other measures of symptoms. Various outcome measures for the QoL domain have also been investigated, with the Quality of Life Index for Atopic Dermatitis (QoLIAD) and the Dermatological Life Quality Index (DLQI) being two of the more preferred measures for eczema clinical trials, although the better of the two is yet to be decided by consensus. HOME is also making progress toward defining the core outcome measure for the long-term control domain, with future consensus meetings planned.

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Authors and Affiliations

  1. Department of Dermatology, St George Hospital, Sydney, NSW, Australia

    Dedee F. Murrell

  2. Sydney Medical School, University of Sydney, Sydney, NSW, Australia

    Cathy Yunjia Zhao & Dedee F. Murrell

  3. Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia

    Dedee F. Murrell

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  1. Cathy Yunjia Zhao
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  2. Dedee F. Murrell
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Correspondence to Dedee F. Murrell .

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  1. Dept Dermatology, 110 Surge Bldg, UCSF School of Medicine Dept Dermatology, 110 Surge Bldg, San Francisco, CA, USA

    Howard Maibach

  2. Department of Dermatology, University of California, San Francisco Department of Dermatology, San Francisco, CA, USA

    Nily Osman

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Zhao, C.Y., Murrell, D.F. (2019). Atopic Dermatitis Outcome Measures. In: Maibach, H., Osman, N. (eds) Cutaneous Biometrics. Springer, Cham. https://doi.org/10.1007/978-3-319-56591-0_49-2

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  1. Latest

    Atopic Dermatitis Outcome Measures
    Published:
    15 February 2019

    DOI: https://doi.org/10.1007/978-3-319-56591-0_49-2

  2. Original

    Atopic Dermatitis Outcome Measures
    Published:
    30 November 2018

    DOI: https://doi.org/10.1007/978-3-319-56591-0_49-1

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