Abstract
Peripheral T-cell lymphomas (PTCLs) represent ≤15% of new non-Hodgkin lymphoma cases. For accurate diagnosis of PTCL, an expert hematopathology review is usually required. Due to the rarity of PTCLs, randomized clinical trials comparing different treatment modalities are lacking, owing to relatively poor outcomes with standard therapies. Chemotherapy is the most common treatment option. Radiotherapy (RT) with RT dose of (30–40) is an efficacious treatment modality in several forms of PTCL in curative or palliative setting. However, early stage extranodal natural killer/T-cell lymphoma (nasal type) requires RT dose ≥50 Gy. Indolent cutaneous lymphoma (mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, follicle center, and marginal zone lymphoma) can be treated successfully with low radiation dose ranging from 4 to 24 Gy. Primary cutaneous diffuse large B cell lymphoma, leg type, requires combined modality (immunochemotherapy and local RT with 36–40 Gy). In patients with diffuse/generalized cutaneous lymphoma, total skin electron beam therapy (TSEBT) is a feasible option, with rapid relief of cutaneous lesions or symptoms. Short-course low-dose TSEBT regimens (10–12 Gy) are very effective with the possibility of combined and/or maintenance therapy administration following TSEBT to prolong the duration of disease remission.
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Eich, H.T., Elsayad, K. (2017). Radiation Therapy in Peripheral T-Cell and Cutaneous Lymphomas. In: Wenz, F. (eds) Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-52619-5_30-1
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DOI: https://doi.org/10.1007/978-3-319-52619-5_30-1
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Radiation Therapy in Peripheral T-Cell and Cutaneous Lymphomas- Published:
- 14 September 2023
DOI: https://doi.org/10.1007/978-3-319-52619-5_30-2
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Radiation Therapy in Peripheral T-Cell and Cutaneous Lymphomas- Published:
- 23 August 2017
DOI: https://doi.org/10.1007/978-3-319-52619-5_30-1