Abstract
The childhood obesity epidemic has been accompanied by an increase in complications of obesity such as the metabolic syndrome and type 2 diabetes. Obese youth with the metabolic syndrome are frequently hypertensive and may present with clinically significant evidence of hypertensive target-organ damage. There are important considerations in the approach to treating hypertension in young patients with the metabolic syndrome or type 2 diabetes, which include the primacy of lifestyle approaches to effect substantial weight loss, increases in exercise, and reduced caloric and salt intake. The cardiovascular effects of oral hypoglycemic agents, and the potentially diabetogenic effects of certain antihypertensive medications must also be considered. A comprehensive approach, including nonpharmacologic measures, the use of hypoglycemic and antihypertensive medications, and perhaps even bariatric surgery in selected patients, is indicated in order to reduce future cardiovascular risk.
References
Abbasi F, Chu JW, McLaughlin T et al (2004) Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus. Metabolism 53:159–164
Aghamohammadzadeh R, Heagerty AM (2012) Obesity-related hypertension: epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue. Ann Med 44(Suppl 1):S74–S84
Anderson EA, Hoffman RP, Balon TW et al (1991) Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 87:2246–2252
Appel LJ, Moore TJ, Obarzanek E et al (1997) A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 336:1117–1124
Appel LJ, Brands MW, Daniels SR et al (2006) Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension 47:296–308
Asfaha S, Padwal R (2005) Antihypertensive drugs and incidence of type 2 diabetes: evidence and implications for clinical practice. Curr Hypertens Rep 7:314–322
Beltran-Sanchez H, Harhay MO, Harhay MM et al (2013) Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999–2010. J Am Coll Cardiol 62:697–703
Ben Ounis O, Elloumi M, Ben Chiekh I et al (2008) Effects of two-month physical-endurance and diet-restriction programmes on lipid profiles and insulin resistance in obese adolescent boys. Diabetes Metab 34:595–600
Berenson GS, Srinivasan SR, Bao W et al (1998) Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study N Engl J Med 338:1650–1656
Brown NJ (2012) Cardiovascular effects of antidiabetic agents: focus on blood pressure effects of incretin-based therapies. J Am Soc Hypertens 6:163–168
Chiasson JL (2006) Acarbose for the prevention of diabetes, hypertension, and cardiovascular disease in subjects with impaired glucose tolerance: the Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) Trial. Endocr Pract 12(Suppl 1):25–30
Chobanian AV, Bakris GL, Black HR et al (2003) The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 289:2560–2572
Cook S, Weitzman M, Auinger P et al (2003) Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988–1994. Arch Pediatr Adolesc Med 157:821–827
Copeland KC, Zeitler P, Geffner M et al (2011) Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab 96:159–167
Cosenso-Martin LN, Giollo-Junior LT, Vilela-Martin JF (2015) DPP-4 inhibitor reduces central blood pressure in a diabetic and hypertensive patient: a case report. Medicine (Baltimore) 94:e1068
Couch SC, Saelens BE, Levin L et al (2008) The efficacy of a clinic-based behavioral nutrition intervention emphasizing a DASH-type diet for adolescents with elevated blood pressure. J Pediatr 152:494–501
Daniels SR, Arnett DK, Eckel RH et al (2005) Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatment. Circulation 111:1999–2012
Derosa G, Cicero AF, Gaddi AV et al (2005) Long-term effects of glimepiride or rosiglitazone in combination with metformin on blood pressure control in type 2 diabetic patients affected by the metabolic syndrome: a 12-month, double-blind, randomized clinical trial. Clin Ther 27:1383–1391
Eckel RH, Alberti KG, Grundy SM et al (2010) The metabolic syndrome. Lancet 375:181–183
Eppens MC, Craig ME, Cusumano J et al (2006a) Prevalence of diabetes complications in adolescents with type 2 compared with type 1 diabetes. Diabetes Care 29:1300–1306
Eppens MC, Craig ME, Jones TW et al (2006b) Type 2 diabetes in youth from the Western Pacific region: glycaemic control, diabetes care and complications. Curr Med Res Opin 22:1013–1020
Esler M, Rumantir M, Wiesner G et al (2001) Sympathetic nervous system and insulin resistance: from obesity to diabetes. Am J Hypertens 14:304S–309S
Ettinger LM, Freeman K, Dimartino-Nardi JR et al (2005) Microalbuminuria and abnormal ambulatory blood pressure in adolescents with type 2 diabetes mellitus. J Pediatr 147:67–73
Falkner B, Kushner H (2008) Treatment with metoprolol succinate, a selective beta adrenergic blocker, lowers blood pressure without altering insulin sensitivity in diabetic patients. J Clin Hypertens (Greenwich) 10:51–57
Falkner B, Michel S (1997) Blood pressure response to sodium in children and adolescents. Am J Clin Nutr 65:618S–621S
Farpour-Lambert NJ, Aggoun Y, Marchand LM et al (2009) Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in pre-pubertal obese children. J Am Coll Cardiol 54:2396–2406
Flynn JT, Alderman MH (2005) Characteristics of children with primary hypertension seen at a referral center. Pediatr Nephrol 20:961–966
Ford ES, Giles WH, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287:356–359
Gillespie EL, White CM, Kardas M, Lindberg M, Coleman CI (2005) The impact of ACE inhibitors or angiotensin II type 1 receptor blockers on the development of new-onset type 2 diabetes. Diabetes Care 28:2261–2266
Giorda C, Appendino M, Mason MG et al (1995) Alpha 1-blocker doxazosin improves peripheral insulin sensitivity in diabetic hypertensive patients. Metabolism 44:673–676
Goodman E, Daniels SR, Meigs JB et al (2007) Instability in the diagnosis of metabolic syndrome in adolescents. Circulation 115:2316–2322
Hall JE (2003) The kidney, hypertension, and obesity. Hypertension 41:625–633
Harano Y, Kageyama A, Hirose J et al (1995) Improvement of insulin sensitivity for glucose metabolism with the long-acting Ca-channel blocker amlodipine in essential hypertensive subjects. Metabolism 44:315–319
Hypertension in Diabetes Study (HDS) (1993) Hypertension in Diabetes Study (HDS): I. Prevalence of hypertension in newly presenting type 2 diabetic patients and the association with risk factors for cardiovascular and diabetic complications. Journal of Hypertension 11:309–17
Inge TH, Courcoulas AP, Jenkins TM et al (2016) Weight loss and health status 3 years after bariatric surgery in adolescents. N Engl J Med 374:113–123
Ingelfinger JR (2011) Bariatric surgery in adolescents. N Engl J Med 365:1365–1367
Inukai T, Inukai Y, Matsutomo R et al (2004) Clinical usefulness of doxazosin in patients with type 2 diabetes complicated by hypertension: effects on glucose and lipid metabolism. J Int Med Res 32:206–213
Izzedine H, Launay-Vacher V, Deybach C et al (2005) Drug-induced diabetes mellitus. Expert Opin Drug Saf 4:1097–1109
James PA, Oparil S, Carter BL et al (2014) 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311:507–520
Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840–846
Kamide K, Hori MT, Zhu JH et al (2000) Insulin and insulin-like growth factor-I promotes angiotensinogen production and growth in vascular smooth muscle cells. J Hypertens 18:1051–1056
Kit BK, Kuklina E, Carroll MD et al (2015) Prevalence of and trends in dyslipidemia and blood pressure among US children and adolescents, 1999–2012. JAMA Pediatr 169:272–279
Knowler WC, Barrett-Connor E, Fowler SE et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393–403
Koyama Y, Kodama K, Suzuki M et al (2002) Improvement of insulin sensitivity by a long-acting nifedipine preparation (nifedipine-CR) in patients with essential hypertension. Am J Hypertens 15:927–931
Laakso M, Edelman SV, Brechtel G et al (1990) Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest 85:1844–1852
Landsberg L (2001) Insulin-mediated sympathetic stimulation: role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why). J Hypertens 19:523–528
Lawrence JM, Mayer-Davis EJ, Reynolds K et al (2009) Diabetes in Hispanic American youth: prevalence, incidence, demographics, and clinical characteristics: the SEARCH for diabetes in youth study. Diabetes Care 32(Suppl 2):S123–S132
Lee S, Bacha F, Arslanian SA (2006) Waist circumference, blood pressure, and lipid components of the metabolic syndrome. J Pediatr 149:809–816
Liska D, Dufour S, Zern TL et al (2007) Interethnic differences in muscle, liver and abdominal fat partitioning in obese adolescents. PLoS One 2:e569
Love-Osborne K, Sheeder J, Zeitler P (2008) Addition of metformin to a lifestyle modification program in adolescents with insulin resistance. J Pediatr 152:817–822
Lurbe E, Agabiti-Rosei E, Cruickshank JK et al (2016) 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens 34:1887–1920
Majithiya JB, Balaraman R (2006) Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats. Life Sci 78:2615–2624
Manzella D, Grella R, Esposito K et al (2004) Blood pressure and cardiac autonomic nervous system in obese type 2 diabetic patients: effect of metformin administration. Am J Hypertens 17:223–227
Marney A, Kunchakarra S, Byrne L et al (2010) Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans. Hypertension 56:728–733
Mason JM, Dickinson HO, Nicolson DJ et al (2005) The diabetogenic potential of thiazide-type diuretic and beta-blocker combinations in patients with hypertension. J Hypertens 23:1777–1781
Mu JJ, Liu ZQ, Liu WM et al (2005) Reduction of blood pressure with calcium and potassium supplementation in children with salt sensitivity: a 2-year double-blinded placebo-controlled trial. J Hum Hypertens 19:479–483
Mugo MN, Link D, Stump CS, Sowers JR (2007) Comprehensive hypertension. Mosby, Inc., Philadelphia
National High Blood Pressure Education Program Working Group on High Blood Pressure in, C. & Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114:555–576
Negro R, Dazzi D, Hassan H et al (2004) Pioglitazone reduces blood pressure in non-dipping diabetic patients. Minerva Endocrinol 29:11–17
Negro R, Mangieri T, Dazzi D et al (2005) Rosiglitazone effects on blood pressure and metabolic parameters in nondipper diabetic patients. Diabetes Res Clin Pract 70:20–25
Officers A, Coordinators for the, A. C. R. G. T. A. & Lipid-Lowering Treatment to Prevent Heart Attack, T (2002) Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 288:2981–2997
Okerson T, Yan P, Stonehouse A et al (2010) Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes. Am J Hypertens 23:334–339
Olza J, Gil-Campos M, Leis R et al (2011) Presence of the metabolic syndrome in obese children at prepubertal age. Ann Nutr Metab 58:343–350
Pershadsingh HA (2006) Treating the metabolic syndrome using angiotensin receptor antagonists that selectively modulate peroxisome proliferator-activated receptor-gamma. Int J Biochem Cell Biol 38:766–781
Preiss D, Lloyd SM, Ford I et al (2014) Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial. Lancet Diabetes Endocrinol 2:116–124
Punzi HA, Punzi CF, Antihypertensive, Lipid-Lowering Heart Attack Trial, S. & Trinity Hypertension Research, I (2004) Metabolic issues in the Antihypertensive and Lipid-Lowering Heart Attack Trial Study. Curr Hypertens Rep 6:106–110
Rachmani R, Bar-Dayan Y, Ronen Z et al (2004) The effect of acarbose on insulin resistance in obese hypertensive subjects with normal glucose tolerance: a randomized controlled study. Diabetes Obes Metab 6:63–68
Reaven GM, Lithell H, Landsberg L (1996) Hypertension and associated metabolic abnormalities – the role of insulin resistance and the sympathoadrenal system. N Engl J Med 334:374–381
Redon J, Cifkova R, Laurent S et al (2009) Mechanisms of hypertension in the cardiometabolic syndrome. J Hypertens 27:441–451
Reinehr T, Andler W (2004) Changes in the atherogenic risk factor profile according to degree of weight loss. Arch Dis Child 89:419–422
Reinehr T, Wunsch R, De Sousa G et al (2008) Relationship between metabolic syndrome definitions for children and adolescents and intima-media thickness. Atherosclerosis 199:193–200
Ribeiro MM, Silva AG, Santos NS et al (2005) Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children. Circulation 111:1915–1923
Ritz E, Dikow R (2006) Hypertension and antihypertensive treatment of diabetic nephropathy. Nat Clin Pract Nephrol 2:562–567
Rocchini AP (2002) Obesity hypertension. Am J Hypertens 15:50S–52S
Rocchini AP, Katch V, Anderson J et al (1988) Blood pressure in obese adolescents: effect of weight loss. Pediatrics 82:16–23
Rocchini AP, Key J, Bondie D et al (1989) The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents. N Engl J Med 321:580–585
Rodriguez BL, Fujimoto WY, Mayer-Davis EJ et al (2006) Prevalence of cardiovascular disease risk factors in U.S. children and adolescents with diabetes: the SEARCH for diabetes in youth study. Diabetes Care 29:1891–1896
Rodriguez BL, Dabelea D, Liese AD et al (2010) Prevalence and correlates of elevated blood pressure in youth with diabetes mellitus: the SEARCH for diabetes in youth study. J Pediatr 157(2):245–251 e1
Ryan MJ, Didion SP, Mathur S et al (2004) PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension 43:661–666
Sarafidis PA, Lasaridis AN, Nilsson PM et al (2004) Ambulatory blood pressure reduction after rosiglitazone treatment in patients with type 2 diabetes and hypertension correlates with insulin sensitivity increase. J Hypertens 22:1769–1777
Scheen AJ (2004) Renin-angiotensin system inhibition prevents type 2 diabetes mellitus. Part 2. Overview of physiological and biochemical mechanisms. Diabetes Metab 30:498–505
Scherrer U, Randin D, Vollenweider P et al (1994) Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 94:2511–2515
Schillaci G, Pirro M, Vaudo G et al (2004) Prognostic value of the metabolic syndrome in essential hypertension. J Am Coll Cardiol 43:1817–1822
Schulman IH, Zhou MS (2009) Vascular insulin resistance: a potential link between cardiovascular and metabolic diseases. Curr Hypertens Rep 11:48–55
SEARCH for Diabetes Group (2006) The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for diabetes in youth study. Pediatrics 118:1510–1518
Sha S, Polidori D, Heise T et al (2014) Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus. Diabetes Obes Metab 16:1087–1095
Shatat IF, Flynn JT (2011) Relationships between renin, aldosterone, and 24-hour ambulatory blood pressure in obese adolescents. Pediatr Res 69:336–340
Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116:1793–1801
Silva GM, Osorio A, Pereira F et al (2012) Effect of laparoscopic adjustable gastric banding on modifiable cardiovascular risk factors in extremely obese adolescents. Obes Surg 22:991–994
Sinaiko AR, Gomez-Marin O, Prineas RJ (1997) Relation of fasting insulin to blood pressure and lipids in adolescents and parents. Hypertension 30:1554–1559
Sinaiko AR, Steinberger J, Moran A et al (2002) Relation of insulin resistance to blood pressure in childhood. J Hypertens 20:509–517
Stakos DA, Schuster DP, Sparks EA et al (2005) Long term cardiovascular effects of oral antidiabetic agents in non-diabetic patients with insulin resistance: double blind, prospective, randomised study. Heart 91:589–594
Stears AJ, Woods SH, Watts MM et al (2012) A double-blind, placebo-controlled, crossover trial comparing the effects of amiloride and hydrochlorothiazide on glucose tolerance in patients with essential hypertension. Hypertension 59:934–942
Steinberger J, Daniels SR, Eckel RH et al (2009) Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation 119:628–647
Suh DC, Kim CM, Choi IS et al (2009) Trends in blood pressure control and treatment among type 2 diabetes with comorbid hypertension in the United States: 1988–2004. J Hypertens 27:1908–1916
Sun SS, Grave GD, Siervogel RM et al (2007) Systolic blood pressure in childhood predicts hypertension and metabolic syndrome later in life. Pediatrics 119:237–246
Tentolouris N, Liatis S, Katsilambros N (2006) Sympathetic system activity in obesity and metabolic syndrome. Ann N Y Acad Sci 1083:129–152
TODAY Study Group (2012) A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med 366:2247–2256
TODAY Study Group (2013) Rapid rise in hypertension and nephropathy in youth with type 2 diabetes: the TODAY clinical trial. Diabetes Care 36:1735–1741
Togashi K, Masuda H, Rankinen T et al (2002) A 12-year follow-up study of treated obese children in Japan. Int J Obes Relat Metab Disord 26:770–777
Torrance B, McGuire KA, Lewanczuk R et al (2007) Overweight, physical activity and high blood pressure in children: a review of the literature. Vasc Health Risk Manag 3:139–149
Urbina E, Alpert B, Flynn J et al (2008) Ambulatory blood pressure monitoring in children and adolescents: recommendations for standard assessment: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young and the Council for High Blood Pressure Research. Hypertension 52:433–451
Urbina EM, Kimball TR, McCoy CE et al (2009) Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function. Circulation 119:2913–2919
Uzunlulu M, Oguz A, Yorulmaz E (2006) The effect of carvedilol on metabolic parameters in patients with metabolic syndrome. Int Heart J 47:421–430
Vague P (2003) Is metformin more than an oral hypoglycaemic agent? Diabetes Metab 29:6S5–6S7
Van Gaal LF, De Block CE (2012) Bariatric surgery to treat type 2 diabetes: what is the recent evidence? Curr Opin Endocrinol Diabetes Obes 19:352–358
Verdecchia P, Angeli F, Reboldi GP et al (2005) New-onset diabetes in treated hypertensive patients. Curr Hypertens Rep 7:174–179
Weber MA, Bakris GL, Jamerson K et al (2010) Cardiovascular events during differing hypertension therapies in patients with diabetes. J Am Coll Cardiol 56:77–85
Weiss R, Dziura J, Burgert TS et al (2004) Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 350:2362–2374
Wellington K (2005) Rosiglitazone/Metformin. Drugs 65:1581–1592. discussion 1593–4
Williams CL, Hayman LL, Daniels SR et al (2002) Cardiovascular health in childhood: a statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 106:143–160
Zhou MS, Schulman IH, Raij L (2010) Vascular inflammation, insulin resistance, and endothelial dysfunction in salt-sensitive hypertension: role of nuclear factor kappa B activation. J Hypertens 28:527–535
Zimmet P, Alberti G, Kaufman F et al (2007a) The metabolic syndrome in children and adolescents. Lancet 369:2059–2061
Zimmet P, Alberti KG, Kaufman F et al (2007b) The metabolic syndrome in children and adolescents – an IDF consensus report. Pediatr Diabetes 8:299–306
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this entry
Cite this entry
Kim, G.J., Taplin, C.E., Flynn, J.T. (2017). Hypertension in Children with Type 2 Diabetes or the Metabolic Syndrome. In: Flynn, J., Ingelfinger, J., Redwine, K. (eds) Pediatric Hypertension. Springer, Cham. https://doi.org/10.1007/978-3-319-31420-4_19-1
Download citation
DOI: https://doi.org/10.1007/978-3-319-31420-4_19-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-31420-4
Online ISBN: 978-3-319-31420-4
eBook Packages: Springer Reference MedicineReference Module Medicine
Publish with us
Chapter history
-
Latest
Hypertension in Children with Type 2 Diabetes or the Metabolic Syndrome- Published:
- 21 May 2022
DOI: https://doi.org/10.1007/978-3-319-31420-4_19-2
-
Original
Hypertension in Children with Type 2 Diabetes or the Metabolic Syndrome- Published:
- 27 May 2017
DOI: https://doi.org/10.1007/978-3-319-31420-4_19-1