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Hyaluronic Acid Dermal Filler: Physical Properties and Its Indications

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Botulinum Toxins, Fillers and Related Substances

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Abstract

In the other chapters of this volume, authors are describing injection techniques and general handling of hyaluronic acid gels. This class of dermal fillers is the mainstay of modern dermal filling practice around the world for the past 20 years. The practicing doctor, while studying the subject further in the medical literature, will most certainly face some debates on the physical properties of hyaluronic acid gels. In this chapter, we summarize and explain the main concepts of hyaluronic acid gel rheology. With this information, doctors should be able to see past commercial and marketing claims and make an educated choice on which products he should employ and what results he should expect.

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References

  • American Society of Plastic Surgeons. American society of plastic surgeons 2016 statistics report; 2016.

    Google Scholar 

  • Artzi O, Loizides C, Verner I, Landau M. Resistant and recurrent late reaction to hyaluronic acid-based gel. Dermatol Surg. 2016;42:31–7.

    Article  CAS  Google Scholar 

  • Belmontesi M, De Angelis F, Di Gregorio C, Iozzo I, Romagnoli M, Salti G, Clementoni MT. Injectable non-animal stabilized hyaluronic acid as a skin quality booster: an expert panel consensus. J Drugs Dermatol. 2018;17:83–8.

    PubMed  Google Scholar 

  • Borrell M. Dustin B Leslie, and Ahmet Tezel. Lift capabilities of hyaluronic acid fillers. J Cosmet Laser Ther. 2011;13:21–7.

    Article  Google Scholar 

  • Buhren BA, Schrumpf H, Hoff N-P, Bölke E, Hilton S, Gerber PA. Hyaluronidase: from clinical applications to molecular and cellular mechanisms. Eur J Med Res. 2016;21:5.

    Article  Google Scholar 

  • De Boulle K, Glogau R, Kono T, Nathan M, Tezel A, Roca-Martinez J-X, Paliwal S, Stroumpoulis D. A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers. Dermatol Surg. 2013;39:1758–66.

    Article  Google Scholar 

  • Dover JS. The filler revolution has just begun. Plast Reconstr Surg. 2006;117(3 suppl):38S.

    Article  Google Scholar 

  • Edsman K, Nord LI, Ohrlund A, Lärkner H, Kenne AH. Gel properties of hyaluronic acid dermal fillers. Dermatol Surg. 2012;38:1170–9.

    Article  CAS  Google Scholar 

  • Edsman KLM, sa M Wiebensjö A°, Risberg AM, Öhrlund JA° k. Is there a method that can measure cohesivity? Cohesion by sensory evaluation compared with other test methods. Dermatol Surg. 2015;41(Suppl 1):S365–72.

    Article  Google Scholar 

  • Falcone SJ, Berg RA. Crosslinked hyaluronic acid dermal fillers: a comparison of rheological properties. J Biomed Mater Res A. 2008;87:264–71.

    Article  Google Scholar 

  • Flynn TC, Sarazin D, Bezzola A, Terrani C, Micheels P. Comparative histology of intradermal implantation of mono and biphasic hyaluronic acid fillers. Dermatol Surg. 2011;37:637–43.

    Article  CAS  Google Scholar 

  • Juhász MLW, Levin MK, Marmur ES. The kinetics of reversible hyaluronic acid filler injection treated with hyaluronidase. Dermatol Surg. June 2017;43:841–7.

    Article  Google Scholar 

  • Kablik J, Monheit GD, LiPing Y, Chang G, Gershkovich J. Comparative physical properties of hyaluronic acid dermal fillers. Dermatol Surg. 2009;35(Suppl 1):302–12.

    Article  CAS  Google Scholar 

  • ke Öhrlund JA°, Edsman KLM. The myth of the “biphasic” hyaluronic acid filler. Dermatol Surg. December 2015;41(Suppl 1):S358–64.

    Article  Google Scholar 

  • Khunmanee S, Jeong Y, Park H. Crosslinking method of hyaluronic-based hydrogel for biomedical applications. J Tissue Eng. 2017;8. https://doi.org/10.1177/2041731417726464.

  • Kogan G, Soltés L, Stern R, Gemeiner P. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett. 2007;29:17–25.

    Article  CAS  Google Scholar 

  • Paul Lorenc Z, ke Öhrlund A°, Edsman K. Factors affecting the rheological measurement of hyaluronic acid gel fillers. J Drugs Dermatol. 2017;16:876–82.

    PubMed  Google Scholar 

  • Pierre S, Liew S, Bernardin A. Basics of dermal filler rheology. Dermatol Surg. 2015;41(Suppl 1):S120–6.

    Article  Google Scholar 

  • Segura S, Anthonioz L, Fuchez F, Herbage B. A complete range of hyaluronic acid filler with distinctive physical properties specifically designed for optimal tissue adaptations. J Drugs Dermatol. 2012;11:s5–8.

    CAS  PubMed  Google Scholar 

  • Sundaram H, Fagien S. Cohesive polydensified matrix hyaluronic acid for fine lines. Plast Reconstr Surg. 2015;136:149S–63S.

    Article  CAS  Google Scholar 

  • Sundaram H, Rohrich RJ, Liew S, Sattler G, Talarico S, Trévidic P, Molliard SG. Cohesivity of hyaluronic acid fillers: development and clinical implications of a novel assay, pilot validation with a five-point grading scale, and evaluation of six U.S. food and drug administration-approved fillers. Plast Reconstr Surg. 2015;136:678–86.

    Article  CAS  Google Scholar 

  • Tezel A, Fredrickson GH. The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther. 2008;10:35–42.

    Article  Google Scholar 

  • Tran C, Carraux P, Icheels P, Kaya G, Salomon D. In vivo bio-integration of three hyaluronic acid fillers in human skin: a histological study. Dermatology. 2014;228:47–54.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Medical Science Liaison at Galderma/Nestlé Skin Health, São Paulo, Brazil

    Marcelo Neira Ave

  2. Department of Clinical Medicine (Dermatology), Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

    Maria Claudia Almeida Issa

Authors
  1. Marcelo Neira Ave
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  2. Maria Claudia Almeida Issa
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Corresponding author

Correspondence to Marcelo Neira Ave .

Editor information

Editors and Affiliations

  1. Universidade Federal Fluminense, Niterói, São Paulo, Brazil

    Maria Claudia Almeida Issa

  2. Lexbios Medica S/S, São Paulo, São Paulo, Brazil

    Bhertha Tamura

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Ave, M.N., Issa, M.C.A. (2019). Hyaluronic Acid Dermal Filler: Physical Properties and Its Indications. In: Issa, M.C.A., Tamura, B. (eds) Botulinum Toxins, Fillers and Related Substances. Clinical Approaches and Procedures in Cosmetic Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-20253-2_39-2

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  • DOI: https://doi.org/10.1007/978-3-319-20253-2_39-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-20253-2

  • Online ISBN: 978-3-319-20253-2

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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Chapter history

  1. Latest

    Hyaluronic Acid Dermal Filler: Physical Properties and Its Indications
    Published:
    04 January 2019

    DOI: https://doi.org/10.1007/978-3-319-20253-2_39-2

  2. Original

    Hyaluronic Acid Dermal Filler: Physical Properties and Its Indications
    Published:
    29 March 2018

    DOI: https://doi.org/10.1007/978-3-319-20253-2_39-1

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