Definition
When exposed to extended periods of weightlessness, the bones lose both size and strength, increasing their risk of fracture.
Introduction
The fact that human crew members lose bone mass during extended spaceflight has been well documented over the last three decades. Less well defined is degree to which fracture risk is elevated, given expected declines in bone mineral density (BMD) and changes in bone geometry, in otherwise healthy and fit crew members. Moderate reductions in BMD pose little risk to crew members as long as they remain in microgravity; it is the transition to work activity in partial or full gravity (g) environments that increases risk of bone fracture. Bone fractures, should they occur during projected exploration-class missions, pose a significant risk to crew health and to achieving mission objectives. The public rarely hears about a related concern that bone loss incurred in-flight might hasten the onset of frank osteoporosis (defined as BMD >2.5...
References
Allen MR, Hogan HA, Bloomfield SA (2006) Differential bone and muscle recovery following hindlimb unloading in skeletally mature male rats. J Musculoskelet Neuronal Interact 6:217–225
Cavanagh P, Licata A, Rice A (2005) Exercise and pharmacological countermeasures for bone loss during long-duration space flight. Gravit Space Biol 18:39–58
Dietrick J, Whedon G, Schorr E (1948) Effects of immobilization upon various metabolic and physiologic functions of normal men. Am J Med 4:3–36
Hamilton SA, Pecaut MJ, Gridley DS, Travis ND, Bandstra ER, Willey JS, Nelson GA, Bateman TA (2006) A murine model for bone loss from therapeutic and space-relevant sources of radiation. J Appl Physiol 101:789–793
Issekutz B, JJ B, Birkhead N, Rodahl K (1966) Effect of prolonged bed rest on urinary calcium output. J Appl Physiol 21:1013–1020
Keyak JH, Koyama AK, LeBlanc A, Lu Y, Lang TF (2009) Reduction in proximal femoral strength due to long-duration spaceflight. Bone 44:449–453
Kohrt WM, Bloomfield SA, Little KD, Nelson ME, Yingling VR (2004) Physical activity and bone health. Med Sci Exerc Sports 36:1985–1996
Kondo H, Yumoto K, Alwood JS, Mojarrab R, Wang D, Almeida EA, Searby ND, Limoli CL, Globus RK (2010) Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse. J Appl Physiol 108:152–161
Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A (2004) Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 19:1006–1012
LeBlanc A, Schneider V, Shackelford L, West S, Oganov V, Bakulin A, Voronin L (2000) Bone mineral and lean tissue loss after long duration space flight. J Musculoskelet Neuronal Interact 1:157–160
LeBlanc A, Matsumoto T, Jones J, Shapiro J, Lang T, Shackelford L, Smith SM, Evans H, Spector E, Ploutz-Snyder R, Sibonga J, Keyak J, Nakamura T, Kohri K, Ohshima H (2013) Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight. Osteoporos Int 24:2105–2114
Rambaut P, Goode A (1985) Skeletal changes during space flight. Lancet 2:1050–1052
Sibonga JD, Evans HJ, Sung HG, Spector ER, Lang TF, Oganov VS, Bakulin AV, Shackelford LC, LeBlanc AD (2007) Recovery of spaceflight-induced bone loss: bone mineral density after long-duration missions as fitted with an exponential function. Bone 41:973–978
Smith SM, Wastney ME, Morukov BV, Larina IM, Nyquist LE, Abrams SA, Taran EN, Shih C, Nillen JL, Davis-Street JE, Rice BL, Lane HW (1999) Calcium metabolism before, during, and after a 3-mo spaceflight: kinetic and biochemical changes. Am J Physiol Regul Integr Comp Physiol 277:R1–R10
Smith SM, Heer MA, Shackelford LC, Sibonga JD, Ploutz-Snyder L, Zwart SR (2012) Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: evidence from biochemistry and densitometry. J Bone Miner Res 27:1896–1906
Vico L, Collet P, Guignandon A, Lafage-Proust M-H, Thomas T, Rehailia M, Alexandre C (2000) Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts. Lancet 355:1607–1611
Vogel J, Whittle M (1976) Bone mineral content changes in the Skylab astronauts. Am J Roentgenol 126:1296–1297
Zeitlin C, Hassler D, Cucinotta F, Ehresmann B, Wimmer-Schweingruber R, Brinza D, Kang S, Weigle G, Bottcher S, Bohm E, Burmeister S, Guo J, Kohler J, Martin C, Posner A, Rafkin S, Reitz G (2013) Measurements of energetic particle radiation in transit to Mars on the Mars Science Laboratory. Science 340:1080–1084
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this entry
Cite this entry
Bloomfield, S.A. (2019). Bone Loss. In: Young, L., Sutton, J. (eds) Encyclopedia of Bioastronautics. Springer, Cham. https://doi.org/10.1007/978-3-319-10152-1_95-1
Download citation
DOI: https://doi.org/10.1007/978-3-319-10152-1_95-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-10152-1
Online ISBN: 978-3-319-10152-1
eBook Packages: Springer Reference EngineeringReference Module Computer Science and Engineering