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Hypnotic Activity

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Drug Discovery and Evaluation: Pharmacological Assays

Abstract

The term “hypnotic” has to be defined. In man, the purpose of taking hypnotics is to obtain a “normal” night’s sleep from which the patient can be aroused without any subsequent hangover. In animal experiments, the term “hypnotic” has been applied to a much deeper stage of central depression of drug induced unconsciousness associated with loss of muscle tone and of righting reflexes. Therefore, most of the pharmacological models are questionable in regard to their predictivity to find an ideal hypnotic for human therapy. Many of the pharmacological tests are based on the potentiation of sleeping time induced by barbiturates or other sedative agents.

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Authors and Affiliations

  1. Kallman Preclinical Consulting, 1569 E. 300 North, Greenfield, IN, 46140, USA

    Mary Jeanne Kallman

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  1. Mary Jeanne Kallman
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Correspondence to Mary Jeanne Kallman .

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  1. CorDynamics, Dieburg, Germany

    Franz J. Hock

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Kallman, M.J. (2016). Hypnotic Activity. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Cham. https://doi.org/10.1007/978-3-319-05392-9_29

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