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Binding Tests in Respiratory System

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Drug Discovery and Evaluation: Pharmacological Assays

Abstract

Histamine receptors have been classified on the basis of pharmacological analysis (Hill et al. 1997). Histamine exerts its action via at least four receptor subtypes. The H1 receptor couples mainly to Gq/11, thereby stimulating phospholipase C, whereas the H2 receptor interacts with Gs to activate adenylyl cyclase. The histamine H3 and H4 receptors couple to Gi proteins to inhibit adenylyl cyclase and to stimulate MAPK (Hough 2001).

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References and Further Reading

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Authors and Affiliations

  1. Integrated Physiology and Pharmacology Consulting, LLC, 25 Bedell Rd, Poughkeepsie, NY, 12603, USA

    Kristy D. Bruse

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  1. Kristy D. Bruse
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Correspondence to Kristy D. Bruse .

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Editors and Affiliations

  1. CorDynamics, Dieburg, Germany

    Franz J. Hock

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© 2016 Springer International Publishing Switzerland

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Bruse, K.D. (2016). Binding Tests in Respiratory System. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Cham. https://doi.org/10.1007/978-3-319-05392-9_22

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