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CARD9 Deficiency

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Encyclopedia of Medical Immunology

Introduction

Despite an estimated 1.5 million species of fungi, ubiquitous in distribution resulting in constant exposure, few cause human disease. Those that do reflect a defect of immunity, either inherent or acquired. Although the taxonomy of fungi and the field of medical mycology are relatively young compared to other fields of microbiology, historical reports of fungi causing nail, hair, and superficial skin infections, as well as invasive disease, can be traced back to the mid-nineteenth century, prior to the advent of advanced therapeutics accounting for modern-day iatrogenic mycoses. Further, rather than causing true epidemics like bacteria and parasites, fungi were recognized to typically cause “sporadic” disease, that is, affecting select individuals, families, or races. The study of primary immunodeficiencies (PID) has led to the identification of critical genes that account, at least in part, for this inherent basis for susceptibility.

Spontaneously occurring fungal...

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Authors and Affiliations

  1. Research Institute-MUHC (RI-MUHC), Montréal, Québec, Canada

    Christina Gavino & Marija Landekic

  2. Infectious Disease Susceptibility Program, McGill University Health Centre (MUHC) and Research Institute-MUHC (RI-MUHC), Montréal, Québec, Canada

    Donald C. Vinh

  3. Department of Medicine, Division of Infectious Diseases & Medical Microbiology, McGill University Health Centre, Montréal, Québec, Canada

    Donald C. Vinh

  4. Department of Human Genetics, McGill University, Montréal, Québec, Canada

    Donald C. Vinh

Authors
  1. Christina Gavino
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  2. Marija Landekic
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  3. Donald C. Vinh
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Correspondence to Donald C. Vinh .

Editor information

Editors and Affiliations

  1. Molecular Biology, Monash University Dept. Biochemistry &, Clayton, Victoria, Australia

    Ian MacKay

  2. Autoimmune Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Noel R. Rose

Section Editor information

  1. Child & Family Research Institute, Vancouver, Canada

    Stuart Turvey

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Gavino, C., Landekic, M., Vinh, D.C. (2018). CARD9 Deficiency. In: MacKay, I., Rose, N. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9209-2_59-2

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  • DOI: https://doi.org/10.1007/978-1-4614-9209-2_59-2

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Chapter history

  1. Latest

    CARD9 Deficiency
    Published:
    26 July 2018

    DOI: https://doi.org/10.1007/978-1-4614-9209-2_59-2

  2. Original

    CARD9 Deficiency
    Published:
    01 September 2017

    DOI: https://doi.org/10.1007/978-1-4614-9209-2_59-1

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