Synonyms
Definition
Migraine is a headache disorder characterized by recurrent episodes of head pain, often throbbing and unilateral, sometimes preceded by neurological symptoms called aura. The known pathophysiologic mechanism suggest that this disorder should be considered as a neurovascular headache. Migraine is a highly disabling disorder according to the World Health Organization – the seventh most disabling in the world and the fourth most disabling among women.
Spreading depression (SD) is essentially a slow (about 3 mm/min = 50 μm/s) reaction–diffusion wave in gray matter tissue during which ion concentrations inside and outside the cells change by over one order of magnitude to a nearly complete elimination of transmembrane chemical gradients, i.e., a nearly complete release of Gibbs free energy with depressed neuronal activity. SD is accompanied by a pronounced hemodynamic response of increased regional cerebral blood flow (hyperemia) for about 2...
References
Akerman S, Holland PR, Goadsby PJ (2011) Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci 12:570–584
Ayata C (2013) Spreading depression and neurovascular coupling. Stroke 44:S87–S89
Barón J, Ruiz M, Palacios-Ceña M, Madeleine P, Guerrero ÁL, Arendt-Nielsen L, Fernández-de-las-Peñas C (2017) Differences in topographical pressure pain sensitivity maps of the scalp between patients with migraine and healthy controls. Headache 57:226–235
Brandes JL (2008) The migraine cycle: patient burden of migraine during and between migraine attacks. Headache 48:430–441
Bressloff PC (2012) Spatiotemporal dynamics of continuum neural fields. J Phys A 45:033001
Cressman JR Jr, Ullah G, Ziburkus J, Schiff SJ, Barreto E (2009) The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics. J Comput Neurosci 26:159–170
Dalkara T, Moskowitz M (2017) Neurobiological basis of migraine. Wiley, Hoboken
Dahlem MA (2013) Migraine generator network and spreading depression dynamics as neuromodulation targets in episodic migraine. Chaos 23:046101
Dahlem MA, Hadjikhani N (2009) Migraine aura: retracting particle-like waves in weakly susceptible cortex. PLoS One 4:e5007
Dahlem MA, Isele TM (2013) Transient localized wave patterns and their application to migraine. J Math Neurosci 3:1–37
Dahlem MA, Graf R, Strong AJ, Dreier JP, Dahlem YA, Sieber M, Hanke W, Podoll K, Schöll E (2010) Two-dimensional wave patterns of spreading depolarization: retracting, re-entrant, and stationary waves. Physica D 239:889–903
Giffin NJ, Ruggiero L, Lipton RB, Silberstein SD, Tvedskov JF, Olesen J, Altman J, Goadsby PJ, Macrae A (2003) Premonitory symptoms in migraine: an electronic diary study. Neurology 60:935–940
Grafstein B (1963) Neural release of potassium during spreading depression. In: Brazier MAB (ed) Brain function, Cortical excitability and steady potentials, vol 1. University of California Press, Berkeley, pp 87–124
Hadjikhani N, Sanchez M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RB, Sorensen AG, Moskowitz MA (2001) Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 98:4687–4692
Hansen JM, Lipton RB, Dodick DW, Silberstein SD, Saper JR, Aurora SK, Goadsby PJ, Charles A (2012) Migraine headache is present in the aura phase: a prospective study. Neurology 79:2044–2049
Hübel N, Schöll E, Dahlem MA (2014) Bistable dynamics underlying excitability of ion homeostasis in neuron models. PLOS Comp Biol 10:e1003551
Hübel N, Dahlem MA (2014) Dynamics from seconds to hours in Hodgkin-Huxley model with time-dependent ion concentrations and buffer reservoirs. PLoS Comp Biol 10:e1003941
Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500
Kager H, Wadman WJ, Somjen GG (2000) Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations. J Neurophysiol 84:495–512
Karatas H, Erdener SE, Gursoy-Ozdemir Y, Lule S, Eren-Kocak E, Sen ZD, Dalkara T (2013) Spreading depression triggers headache by activating neuronal Panx1 channels. Science 339:1092–1095
Lauritzen M (1994) Pathophysiology of the migraine aura. The spreading depression theory. Brain 117:199–210
Miura RM, Huang H, Wylie JJ (2007) Cortical spreading depression: an enigma. Eur Phys J Spec Top 147:287–302
Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R (2010) A neural mechanism for exacerbation of headache by light. Nat Neurosci 13:239–245
Olesen J (2013) The international classification of headache disorders, 3rd edn. (beta version). Cephalalgia 33:629–808
Olesen J, Larsen B, Lauritzen M (1981) Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 9:344–352
Rasmussen BK, Olesen J (1992) Migraine with aura and migraine without aura: an epidemiological study. Cephalalgia 12:221–228
Reshodko LV, Bures J (1975) Computer simulation of reverberating spreading depression in a network of cell automata. Biol Cybern 18:181–189
Santos E, Sánchez-Porras R, Sakowitz OW, Dreier JP, Dahlem MA (2017) Heterogeneous propagation of spreading depolarizations in the lissencephalic and gyrencephalic brain. J Cereb Blood Flow Metab 37:2639–2643
Shapiro BE (2001) Osmotic forces and gap junctions in spreading depression: a computational model. J Comput Neurosci 10:99–120
Somjen GG (2001) Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol Rev 81:1065–1096
Somjen GG, Kager H, Wadman WJ (2008) Computer simulations of neuron-glia interactions mediated by ion flux. J Comput Neurosci 25:349–365
Summ O, Charbit AR, Andreou AP, Goadsby PJ (2010) Modulation of nociceptive transmission with calcitonin gene-related peptide receptor antagonists in the thalamus. Brain 133:2540–2548
Tuckwell HC, Miura RM (1978) A mathematical model for spreading cortical depression. Biophys J 23:257–276
Vincent M, Hadjikhani N (2007) Migraine aura and related phenomena: beyond scotomata and scintillations. Cephalalgia 27:1368–1377
Weiller C, May A, Limmroth V, Juptner M, Kaube H, Schayck RV, Coenen HH, Diener HC (1995) Brain stem activation in spontaneous human migraine attacks. Nat Med 1:658–660
Welch K, Nagesh V, Aurora SK, Gelman N (2001) Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness? Headache 41:629–637
Yao W, Huang H, Miura RM (2011) A continuum neuronal model for the instigation and propagation of cortical spreading depression. Bull Math Biol 73:2773–2790
Zandt BJ, ten Haken B, van Putten MJ, Dahlem MA (2015) How does spreading depression spread? Physiology and modeling. Rev Neurosci 26:183–198
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media, LLC, part of Springer Nature
About this entry
Cite this entry
Dahlem, M.A. (2018). Migraines and Cortical Spreading Depression. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_507-7
Download citation
DOI: https://doi.org/10.1007/978-1-4614-7320-6_507-7
Received:
Accepted:
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-7320-6
Online ISBN: 978-1-4614-7320-6
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences
Publish with us
Chapter history
-
Latest
Migraines and Cortical Spreading Depression- Published:
- 02 July 2018
DOI: https://doi.org/10.1007/978-1-4614-7320-6_507-7
-
Migraines and Cortical Spreading Depression
- Published:
- 02 June 2014
DOI: https://doi.org/10.1007/978-1-4614-7320-6_507-6
-
Original
Migraines and Cortical Spreading Depression- Published:
- 17 February 2014
DOI: https://doi.org/10.1007/978-1-4614-7320-6_507-5