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Computational Analysis of Rodent Spinal CPG

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Encyclopedia of Computational Neuroscience

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Definition

The production of patterned locomotor output by the rodent neuromuscular system is regulated by the central pattern generator(s) of the spinal cord. The rodent spinal CPG is capable of producing a wide range of gaits, and in particular the default “fundamental locomotor rhythm” of walking. Fictive locomotor experiments and transgenic rodent lines have produced a wealth of information about the neuronal constituency and synaptic organization of the rodent spinal CPG, but many neuronal subpopulations have yet to be identified and the full synaptic architecture is far from being definitively mapped out. A few mathematical and computational models have been proposed which (1) integrate experimental results into a unified, interrogable conceptual framework and (2) enable the testing of various hypotheses of CPG organization in silico. The ultimate goal of computational modeling and analysis of the rodent spinal CPG is to link specific network structures and intrinsic neuronal...

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Authors and Affiliations

  1. University of Utah, Salt Lake City, UT, USA

    Dr. W. Erik Sherwood

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  1. Dr. W. Erik Sherwood
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Correspondence to W. Erik Sherwood .

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Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

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Sherwood, W.E. (2014). Computational Analysis of Rodent Spinal CPG. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_40-2

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_40-2

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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Chapter history

  1. Latest

    Computational Analysis of Rodent Spinal CPG
    Published:
    08 May 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_40-2

  2. Original

    Computational Analysis of the Rodent Spinal CPG
    Published:
    06 February 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_40-1

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