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Hippocampus, Model Inhibitory Cells

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Encyclopedia of Computational Neuroscience

Definition

Hippocampus, model inhibitory cells refer to mathematical models of neurons that are designed to represent (GABAergic) inhibitory interneurons in the hippocampus. Specifically, biophysically motivated models of interneurons located in the CA1, CA3, and dentate gyrus (DG) regions of the hippocampus are described. These cellular models have been developed for two main purposes: (i) to examine how their biophysical characteristics affect and control electrophysiological output and (ii) to examine network output given the modeled cellular characteristics. This entry summarizes a comprehensive set of such models.

Detailed Description

Introduction and Background Context

The brain consists of two classes of neurons, excitatory and inhibitory cells. Excitatory cells were typically thought to be long ranging with their connections, whereas inhibitory cells were viewed as “local circuit neurons” or interneurons (Shepherd 2003). Today, it is clear that this is not necessarily the...

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Abbreviations

Ca-L :

L-type calcium. Also referred to as high threshold type, non-inactivating

Ca-N :

N-type calcium

Ca-T :

T-type calcium. Also referred to as low threshold type, inactivating, and associated with post-inhibitory rebound

h-sag :

Hyperpolarization-activated (sag) inward

K-A :

A-type, transient potassium

K-AHP :

AHP potassium. Only calcium dependent, not voltage dependent, apamin sensitive, sometimes referred to as SK, and responsible for slow AHP, but could also be part of medium AHP

K- Ca :

Calcium-dependent potassium. Calcium and voltage dependent, sometimes referred to as BK and responsible for fast AHP aspects

K-D :

Slowly inactivating potassium

K-DR :

Delayed rectifier potassium. HH type

K-DRf :

Fast delayed rectifier

K-DRs :

Slow delayed rectifier

K-M :

Muscarinic, potassium

Na :

Sodium. Transient, HH type

Na-p :

Persistent sodium

AAC :

Axo-axonic cell

AHP :

Afterhyperpolarization

BSC :

Bistratified cell

CB+ :

Calbindin positive

CCK+ :

Cholecystokinin positive

DG :

Dentate gyrus

EPSP :

Excitatory postsynaptic potential

GABA :

γ-aminobutyric acid

GJ :

Gap junction

HH :

Hodgkin–Huxley

HIPP :

Hilar perforant path associated

IS3 :

Interneuron-specific-III

LM/RAD :

Lacunosum-moleculare/radiatum

MPO :

Membrane potential oscillation

MS :

Medial septum

N/A :

Not applicable

NGL :

Neurogliaform

O/A :

Oriens/alveus

O–LM :

Oriens–lacunosum/pyramidale

PV+ :

Parvalbumin positive

SCA :

Schaffer collateral associated

SOM+ :

Somatostatin positive

SP :

Stratum pyramidale

VGC :

Voltage-gated channel

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Acknowledgments

FKS would like to thank NSERC of Canada for their support over the years.

Author information

Authors and Affiliations

  1. Krembil Research Institute, University Health Network, Toronto, ON, Canada

    Frances K. Skinner & Katie A. Ferguson

  2. Medicine (Neurology) and Physiology, University of Toronto, Toronto, ON, Canada

    Frances K. Skinner

Authors
  1. Frances K. Skinner
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  2. Katie A. Ferguson
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Corresponding author

Correspondence to Frances K. Skinner .

Editor information

Editors and Affiliations

  1. Atlanta, GA, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, FL, USA

    Ranu Jung

Section Editor information

  1. Krembil Research Institute, University Health Network, Toronto, ON, Canada

    Frances K. Skinner

  2. Medicine (Neurology) and Physiology, University of Toronto, Toronto, ON, Canada

    Frances K. Skinner

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Skinner, F.K., Ferguson, K.A. (2018). Hippocampus, Model Inhibitory Cells. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_29-2

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_29-2

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Chapter history

  1. Latest

    Hippocampus, Model Inhibitory Cells
    Published:
    19 September 2018

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_29-2

  2. Original

    Hippocampus, Model Inhibitory Cells
    Published:
    13 February 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_29-1

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