Abstract
Oxygen measurement in human tissues is very important for informed clinical decisions. This chapter provides an overview of several sensing paradigms that are used for this purpose, such as the Clark electrode, fluorescence quenching, PEBBLEs, optodes, near-infrared spectroscopy, and pulse oximetry. The challenges of designing monolithic low-power pulse oximeter biochips are discussed in detail. Design techniques focused on lowering the oximeter’s power consumption are presented, along with a biochip implementing the first sub-mW fully integrated pulse oximeter front-end.
References
Brazy JE, Lewis DV, Mitnick MH, van der Vliet JFFJ (1985) Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations. Pediatrics 75:217–225
Clark LC Jr (1956) Monitor and control of blood and tissue oxygen tensions. ASAIO J 2:41–48
Elwell CE, Cope M, Edwards AD et al. (1992) Measurement of cerebral blood flow in adult humans using near infrared spectroscopy – methodology and possible errors. Adv Exp Med Biol 317:235–45.
Glaros KN (2012) Low-power pulse oximetry and transimpedance amplifiers. Dissertation, Imperial College London
Glaros KN, Drakakis EM (2012) A sub-mW fully-integrated pulse oximeter front-end. IEEE Trans Biomed Circuits Syst. doi:10.1109/TBCAS.2012.2200677
Goldman JM, Petterson MT, Kopotic RJ, Barker SJ (2000) Masimo signal extraction pulse oximetry. J Clin Monit Comput 16:475–483
Graeme JG (1995) Photodiode amplifiers: op amp solutions. McGraw-Hill Professional, Boston
Greisen G (2006) Is near-infrared spectroscopy living up to its promises? Semin Fetal Neonatal Med 11:498–502. doi:10.1016/j.siny.2006.07.010
Hayes MJ, Smith PR (2001) A new method for pulse oximetry possessing inherent insensitivity to artifact. IEEE Trans Biomed Eng 48:452–461
Jobsis F (1977) Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198(80):1264–1267. doi:10.1126/science.929199
Lee Y-EK, Smith R, Kopelman R (2009) Nanoparticle PEBBLE sensors in live cells and in vivo. Annu Rev Anal Chem (Palo Alto, Calif) 2:57–76. doi:10.1146/annurev.anchem.1.031207.112823
Mannheimer PD (2007) The light – tissue interaction of pulse oximetry. Anesth Analg 105:S10
Montgomery H, Horwitz O (1950) Oxygen tension of tissues by the polarographic method. I. Introduction: oxygen tension and blood flow of the skin of human extremities. J Clin Invest 29:1120–1130. doi:10.1172/JCI102349
Pujary CJ (2004) Investigation of photodetector optimization in reducing power consumption by a noninvasive pulse oximeter sensor. Dissertation, Worcester Polytechnic Institute
Sasaki K, Shi Z, Kopelman R, Masuhara H (1996) Three-dimensional pH microprobing with an optically-manipulated fluorescent particle. Chem Lett 2:141–142
Severinghaus JW (2004) First electrodes for blood PO2 and PCO2 determination. J Appl Physiol 97:1599–1600
Siegemund M, van Bommel J, Ince C (1999) Assessment of regional tissue oxygenation. Intensive Care Med 25:1044–1060
Sokwoo R, Boo-Ho Y, Asada HH (2001) Artifact-resistant power-efficient design of finger-ring plethysmographic sensors. IEEE Trans Biomed Eng 48:795–805
Tavakoli MD (2006) An analog VLSI front end for pulse oximetry. Dissertation, MIT
Webster JG (1997) Design of pulse oximeters. Institute of Physics Publications, Bristol/Philadelphia
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Glaros, K.N., Rogers, M.L., Boutelle, M.G., Drakakis, E.M. (2017). Sensors for Vital Signs: Oxygen Sensors. In: Sawan, M. (eds) Handbook of Biochips. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6623-9_3-1
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DOI: https://doi.org/10.1007/978-1-4614-6623-9_3-1
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