Skip to main content

Electrical Biosensors: Peripheral Nerve Sensors

  • Living reference work entry
  • First Online:
Handbook of Biochips

Abstract

The chapter provides an overview of techniques for sensing activity from peripheral nerves. It describes the measurement chain from the origin of the signal source and the acquisition of signals from electrodes to their amplification. Discussion of the concepts of interfacing with biological systems is explained from the concept of the electronic engineer. The biological signals are in some cases stochastic and difficult to extract with often unexpected and poorly defined differential mode interference sources, which degrade the signals. Tissue and electrode impedances behave quite differently from simple lumped components and depend on many factors. Additionally, precautions have to be taken to ensure the safety of the body in which the electronics are implanted. This chapter provides an introductory background and tools for implementing a measurement chain for peripheral nerve sensing, helping the reader to acquire an appreciation of the design challenges.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • American National Standard ANSI/AAMI NS15:1995 (1995) Implantable nerve stimulators

    Google Scholar 

  • Andreasen LN, Struijk JJ, Lawrence S (2000) Measurement of the performance of nerve cuff electrodes for recording. Med Biol Eng Comput 38(4):447–453

    Article  Google Scholar 

  • Burke MJ, Gleeson DT (2000) A micropower dry-electrode ECG preamplifier. IEEE Trans Biomed Eng 47(2):155–162

    Article  Google Scholar 

  • Cogan SF (2008) Neural stimulation and recording electrodes. Annu Rev Biomed Eng 10:275–309

    Article  Google Scholar 

  • Demosthenous A (2014) Advances in microelectronics for implantable medical devices. Adv Electron 2014:21. doi:10.1155/2014/981295

    Article  Google Scholar 

  • Demosthenous A, Triantis IF (2005) An adaptive ENG amplifier for tripolar cuff electrodes. IEEE J Solid-State Circuits 40(2):412–421

    Article  Google Scholar 

  • Demosthenous A, Pachnis I, Jiang D, Donaldson N (2013) An integrated amplifier with passive neutralization of myoelectric interference from neural recording tripoles. IEEE Sensors J 13(9):3236–3248

    Article  Google Scholar 

  • Donaldson N, Zhou L, Perkins TA, Munih M, Haugland M, Sinkjaer T (2003) Implantable telemeter for long-term electroneurographic recordings in animals and humans. Med Biol Eng Comput 41(6):654–664

    Article  Google Scholar 

  • Gray PR, Meyer RG (2001) Analysis and design of analog integrated circuits. Wiley, New York

    Google Scholar 

  • Grimnes S, Martinsen ØG (2008) Bioimpedance and bioelectricity basics. Elsevier, Amsterdam

    Google Scholar 

  • Haugland MK, Hoffer J (1994) Artifact-free sensory nerve signals obtained from cuff electrodes during functional electrical stimulation of nearby muscles. IEEE Trans Rehabil Eng 2(1):37–40

    Article  Google Scholar 

  • Jackson WF, Duling BR (1983) Toxic effects of silver-silver chloride electrodes on vascular smooth muscle. Circ Res 53(1):105–108

    Article  Google Scholar 

  • Kurstjens GA (2005) Intraoperative recording of electroneurographic signals from cuff electrodes on extradural sacral roots in spinal cord injured patients. J Urol 174(4 Pt 1):1482–1487

    Article  Google Scholar 

  • Kurtyka B, de Levie R (1992) Frequency dispersion associated with a non-homogeneous interfacial capacitance. J Electroanal Chem 322(1–2):63–77

    Article  Google Scholar 

  • Liu X, Demosthenous A, Donaldson N (2008) Platinum electrode noise in the ENG spectrum. Med Biol Eng Comput 46(10):997–1003

    Article  Google Scholar 

  • Mann DM (2014) Peripheral nerves. In: The nervous system in action. Available at http://michaeldmann.net/mann12.html. Accessed 15 Mar 2014

  • Micera S et al (2011) Decoding of grasping information from neural signals recorded using peripheral intrafascicular interfaces. J Neureng Rehabil 8:53. doi:10.1186/1743-0003-8-53

    Article  Google Scholar 

  • Nielsen T, Sevcencu C, Struijk J (2013) Comparison of mono-, bi-, and tripolar configurations for stimulation and recording with an interfascicular interface. IEEE Trans Neural Syst Rehabil Eng 22(1):88–95

    Article  Google Scholar 

  • Pachnis I, Demosthenous A, Donaldson N (2009) Realization of constant phase element in metallic electrodes for interference reduction in neural recording tripoles. In: World congress on medical physics and biomedical engineering. Springer. doi: 10.1007/978-3-642-03889-1_95

    Google Scholar 

  • Sansen WMC (2007) Analog design essentials. Springer, Dordrecht

    Google Scholar 

  • Schrama J (1957) On the phenomenological theory of linear relaxation processes. Leiden University, Netherlands

    Google Scholar 

  • Spinelli EM, Pallàs-Areny R, Mayosky MA (2003) AC-coupled front-end for biopotential measurements. IEEE Trans Biomed Eng 50(3):391–395

    Article  Google Scholar 

  • Stein RB, Pearson KG (1971) Predicted amplitude and form of action potentials recorded from unmyelinated nerve fibres. J Theor Biol 32(3):539–558

    Article  Google Scholar 

  • Wang JC (1987) Realizations of generalized warburg impedance with RC ladder networks and transmission lines. J Electrochem Soc 134(8):1915

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andreas Demosthenous .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this entry

Cite this entry

Eder, C., Demosthenous, A. (2015). Electrical Biosensors: Peripheral Nerve Sensors. In: Sawan, M. (eds) Handbook of Biochips. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6623-9_28-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6623-9_28-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6623-9

  • eBook Packages: Springer Reference EngineeringReference Module Computer Science and Engineering

Publish with us

Policies and ethics