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Immunology of Osteoporosis

  • Living reference work entry
  • First Online:
Handbook of Immunosenescence

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Abstract

In healthy bone, resorption and formation are balanced. Bone metabolism involves different cells and is influenced by many regulatory factors: age, genetics, mechanical stimulus, hormones, endocrine diseases, and medication. Disturbances in bone metabolism may lead to osteoporosis, a frequent disease in postmenopausal women, elderly subjects, patients suffering from inflammatory diseases, as well as patients who need glucocorticoids or immunosuppressive medication. Osteoclasts and immune cells share the same progenitors, the same microenvironment, and a number of regulatory molecules as well. The tight connection between the bone and immune cells explains the cross talk between these systems. In this chapter, the negative effects of the decline of ovarian function, senescence-associated inflammaging, pro-inflammatory cytokines expressed by immune cells, and immunosuppressive therapy on bone metabolism are described, and especially immunological aspects are highlighted. Studies further evaluating the cross talk between the bone and immune cells may lead to new, even more effective therapeutic strategies for the prevention and treatment of primary and secondary osteoporosis.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Medical University of Vienna, Vienna, Austria

    Katharina Kerschan-Schindl

  2. Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria

    Elena Nebot Valenzuela & Peter Pietschmann

  3. Department of Physiology and Department of Preventive Medicine and Public Health, School of Pharmacy, University of Granada, Granada, Spain

    Elena Nebot Valenzuela

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  1. Katharina Kerschan-Schindl
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  2. Elena Nebot Valenzuela
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  3. Peter Pietschmann
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Correspondence to Peter Pietschmann .

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Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, Québec, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

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Kerschan-Schindl, K., Valenzuela, E.N., Pietschmann, P. (2018). Immunology of Osteoporosis. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_153-1

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