Handbook of Immunosenescence

Basic Understanding and Clinical Implications

  • Tamas Fulop
  • Claudio Franceschi
  • Katsuiku Hirokawa
  • Graham Pawelec
Living reference work

Table of contents

  1. Helen R. Griffiths, Golam Yahia
  2. Wan Wang, Feng Qian, Ruth R. Montgomery
  3. Masanori Utsuyama, Yuko Yoshida-Kikuchi, Masanobu Kitagawa, Katsuiku Hirokawa
  4. Kornelis S. M. van der Geest, Elisabeth Brouwer, W. H. Abdulahad, Annemieke M. H. Boots
  5. Xiang Ding, Joseph B. Margolick, Sean X. Leng
  6. Alejandra Pera, María Luisa Pita-López, Carmen Campos, Fakhri Hassouneh, Nelson Lopez-Sejas, Beatriz Sánchez-Correa et al.
  7. Stephen Boag, Emanuele Andreano, Carmen Martin-Ruiz, Ioakim Spyridopoulos
  8. Esaki M. Shankar, Alireza Saeidi, Ramachandran Vignesh, Vijayakumar Velu, Marie Larsson
  9. Reba Umberger, Bonnie Callen, Mary Lynn Brown
  10. Felix Krenzien, Sandra El Hajj, Stefan G. Tullius, Steven Gabardi
  11. Beatriz Sánchez-Correa, Carmen Campos, Alejandra Pera, Juan M. Bergua, Esther Duran, Rafael Solana et al.
  12. Pascale Baden, Silvia De Cicco, Cong Yu, Michela Deleidi
  13. Julia Marschallinger, Kira Irving Mosher, Tony Wyss-Coray

About this book


“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”


Immunosenescence Immunity T-cells Aging Age-associated pathologies Gerontology Inflamm-aging

Editors and affiliations

  • Tamas Fulop
    • 1
  • Claudio Franceschi
    • 2
  • Katsuiku Hirokawa
    • 3
  • Graham Pawelec
    • 4
  1. 1.Division of Geriatrics Research Center on AgingUniversity of Sherbrooke Dept. of MedicineSherbrookeCanada
  2. 2.Dept of Experimental PathologyUniversity of BolognaBolognaItaly
  3. 3.Institute for Health and Life SciencesTokyoJapan
  4. 4.Center for Medical ResearchUniversity of TübingenTübingenGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-64597-1
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Online ISBN 978-3-319-64597-1
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