Abstract
Endometriosis is a disease that is associated with severe pelvic pain and is a major cause of infertility in women. It is an enigmatic disease whose etiology and pathophysiology has been studied to a limited extent. The events associated with the establishment of the disease and mechanisms associated with infertility are difficult to assess in a systemic manner in women. In order to understand the early and progressive events associated with the establishment of the disease, we have developed a baboon model in which the disease can be induced. This induction manifests itself in a manner that recapitulates the spontaneous disease. The advantage of the induced model is that the progressive changes in both the ectopic and eutopic endometrium can be studied in a nonhuman primate model at specific times during the menstrual cycle and as the disease process continues.
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© 2006 Humana Press Inc.
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Fazleabas, A.T. (2006). A Baboon Model for Inducing Endometriosis. In: Soares, M.J., Hunt, J.S. (eds) Placenta and Trophoblast. Methods in Molecular Medicine™, vol 121. Humana Press. https://doi.org/10.1385/1-59259-983-4:093
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DOI: https://doi.org/10.1385/1-59259-983-4:093
Publisher Name: Humana Press
Print ISBN: 978-1-58829-404-3
Online ISBN: 978-1-59259-983-7
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