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siRNA Delivery In Vivo

  • Protocol
RNA Silencing

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 309))

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Abstract

Inhibition of gene expression at the mRNA levels can be accomplished by several methods, including ribozymes, DNAzymes, and small interfering RNAs (siRNAs) (1–3). This is now driven predominantly by siRNAs, as they are not technically demanding as traditional antisense and ribozyme technologies (4,5). The success of siRNAs as therapeutics, however, is largely dependent on the development of a delivery vehicle that can efficiently deliver them in vivo.

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Acknowledgments

The Norwegian Cancer Society supported this work. We thank Dr. Anne Dybwad for critical reading of the manuscript.

Author information

Authors and Affiliations

  1. Molecular Medicine Group, Institute for Cancer Research, Oslo, Norway

    Mouldy Sioud

Authors
  1. Mouldy Sioud
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Editor information

Editors and Affiliations

  1. Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT

    Gordon G. Carmichael

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© 2005 Humana Press Inc.

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Sioud, M. (2005). siRNA Delivery In Vivo. In: Carmichael, G.G. (eds) RNA Silencing. Methods in Molecular Biology™, vol 309. Humana Press. https://doi.org/10.1385/1-59259-935-4:237

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  • DOI: https://doi.org/10.1385/1-59259-935-4:237

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-436-4

  • Online ISBN: 978-1-59259-935-6

  • eBook Packages: Springer Protocols

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