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A Multianalyte Method for the Quantification of Current-Use Pesticides in Human Serum or Plasma Using Isotope Dilution Gas Chromatography-High-Resolution Mass Spectrometry

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Pesticide Protocols

Part of the book series: Methods in Biotechnology ((MIBT,volume 19))

Abstract

We propose a sensitive and accurate analytical method for quantifying 29 current-use pesticides in human serum or plasma. These pesticides include organophosphates, carbamates, chloroacetanilides, and synthetic pyrethroids, pesticides used in both agricultural and residential settings. Our method employs simple solid-phase extraction followed by highly selective analysis using isotope dilution gas chromatography-high-resolution mass spectrometry. The method is very accurate, has limits of detection (LODs) in the low picogram/gram range, and has coefficients of variation that are typically less than 20% at the low picogram/gram end of the method linear range.

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Author information

Authors and Affiliations

  1. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA

    Dana B. Barr, Roberto Bravo, John R. Barr & Larry L. Needham

Authors
  1. Dana B. Barr
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  2. Roberto Bravo
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  3. John R. Barr
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  4. Larry L. Needham
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Editor information

Editors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Sciences, University of Almería, Almería, Spain

    José L. Martínez Vidal  & Antonia Garrido Frenich  & 

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© 2006 Humana Press Inc.

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Barr, D.B., Bravo, R., Barr, J.R., Needham, L.L. (2006). A Multianalyte Method for the Quantification of Current-Use Pesticides in Human Serum or Plasma Using Isotope Dilution Gas Chromatography-High-Resolution Mass Spectrometry. In: Martínez Vidal, J.L., Frenich, A.G. (eds) Pesticide Protocols. Methods in Biotechnology, vol 19. Humana Press. https://doi.org/10.1385/1-59259-929-X:035

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  • DOI: https://doi.org/10.1385/1-59259-929-X:035

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-410-4

  • Online ISBN: 978-1-59259-929-5

  • eBook Packages: Springer Protocols

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