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Synthesis of Cell-Penetrating Peptides for Cargo Delivery

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Peptide Synthesis and Applications

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 298))

Abstract

Cell-penetrating peptides (CPPs) have served as vehicles for the delivery of different molecules and particles into cells. The efficiency and noninvasive nature of peptide-mediated cellular transduction provides a promising tool for biomedical research. Studies of cell-penetrating constructs that deliver oligonucleotides, peptides, and proteins have elucidated several important cellular signaling mechanisms. Here we briefly describe the major classes of cell-penetrating peptides. We also present various strategies used to couple different cargoes to CPPs.

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Author information

Authors and Affiliations

  1. Estonian Biocentre, Tartu, Estonia

    Margus Pooga

  2. Department of Neurochemistry and Neurotoxicology, ArrheniusLaboratories, Stockholm University, Stockholm, Sweden

    lo Langel

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  1. Margus Pooga
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  2. lo Langel
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Editors and Affiliations

  1. Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, Wolverhampton, UK

    John Howl

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© 2005 Humana Press Inc., Totowa, NJ

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Pooga, M., Langel, l. (2005). Synthesis of Cell-Penetrating Peptides for Cargo Delivery. In: Howl, J. (eds) Peptide Synthesis and Applications. Methods in Molecular Biology™, vol 298. Humana Press. https://doi.org/10.1385/1-59259-877-3:077

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  • DOI: https://doi.org/10.1385/1-59259-877-3:077

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-317-6

  • Online ISBN: 978-1-59259-877-9

  • eBook Packages: Springer Protocols

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