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Structural and Functional Diversity of Glycoconjugates

A Formidable Challenge to the Glycoanalyst

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Capillary Electrophoresis of Carbohydrates

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 213))

Abstract

Glycoconjugates represent the most structurally and functionally diverse molecules in nature. They range in complexity from relatively simple glycosphingolipids and nuclear or cytosolic glycoproteins with dynamic monosaccharide modifications to extraordinarily complex mucins and proteoglycans (for review, see refs. 1,2). Some of the proteoglycans are perhaps the most complex molecules in biology, with more than 100 different saccharide side chains on a single polypeptide. We now realize that most proteins, even those within intracellular compartments, are co- and/or post-translationally modified by covalent attachment of saccharides (3).

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Authors and Affiliations

  1. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Gerald W. Hart

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  1. Gerald W. Hart
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Editors and Affiliations

  1. Caprion Pharmaceuticals, Montreal, Quebec, Canada

    Pierre Thibault

  2. Faculty of Pharmaceutical Sciences, Kinki University, Japan

    Susumu Honda

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© 2003 Humana Press Inc.

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Hart, G.W. (2003). Structural and Functional Diversity of Glycoconjugates. In: Thibault, P., Honda, S. (eds) Capillary Electrophoresis of Carbohydrates. Methods in Molecular Biology™, vol 213. Humana Press. https://doi.org/10.1385/1-59259-294-5:3

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  • DOI: https://doi.org/10.1385/1-59259-294-5:3

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-826-4

  • Online ISBN: 978-1-59259-294-4

  • eBook Packages: Springer Protocols

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