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Functional Analysis of the β2 Integrins

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Integrin Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 129))

Abstract

The interaction of integrins with their ligands is an essential step in regulating many cellular functions (1). The β2 integrins, which are exclusively expressed on leukocytes, are of critical importance for leukocyte functions (2–5). The discovery of an inherited defect in leukocyte adhesion (called leukocyte adhesion deficiency, LAD), caused by the lack of expression of β2 integrins on the cell surface, underscored the important biological role of these receptors in the inflammatory and immune responses (6).

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Author information

Authors and Affiliations

  1. Leukocyte Biology and Inflammation Program, Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachussetts, USA

    Rui Li & M. Amin Arnaout

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  1. Rui Li
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  2. M. Amin Arnaout
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Editors and Affiliations

  1. Berlex Biosciences, Richmond, California, USA

    Anthony Howlett

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© 1999 Humana Press Inc.

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Li, R., Arnaout, M.A. (1999). Functional Analysis of the β2 Integrins. In: Howlett, A. (eds) Integrin Protocols. Methods in Molecular Biology, vol 129. Humana Press. https://doi.org/10.1385/1-59259-249-X:105

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  • DOI: https://doi.org/10.1385/1-59259-249-X:105

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-569-0

  • Online ISBN: 978-1-59259-249-4

  • eBook Packages: Springer Protocols

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