Chemical Construction of Immunotoxins

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 25)


Immunotoxins (ITs) are chimeric proteins consisting of an antibody linked to a toxin. The antibody confers specificity (ability to recognize and react with the target), whereas the toxin confers cytotoxicity (ability to kill the target) (1, 2, 3). ITs have been used in both mice and humans to eliminate tumor cells, autoimmune cells, and virus-infected cells (4, 5, 6.


Disulfide Bond Sulfhydryl Group Cyanuric Chloride Sodium Cyanoborohydride Sodium Metaperiodate 
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Copyright information

© Humana Press Inc. 2000

Authors and Affiliations

  1. 1.Department of Microbiology and Cancer Immunobiology CenterThe University of Texas South Western Medical Center at Dallas

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