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Chemical Construction of Immunotoxins

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Drug Targeting

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 25))

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Abstract

Immunotoxins (ITs) are chimeric proteins consisting of an antibody linked to a toxin. The antibody confers specificity (ability to recognize and react with the target), whereas the toxin confers cytotoxicity (ability to kill the target) (1–3). ITs have been used in both mice and humans to eliminate tumor cells, autoimmune cells, and virus-infected cells (4–6.

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Authors and Affiliations

  1. Department of Microbiology and Cancer Immunobiology Center, The University of Texas South Western Medical Center at Dallas, TX

    Victor Ghetie & Ellen S. Vitetta

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  1. Victor Ghetie
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  2. Ellen S. Vitetta
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Editors and Affiliations

  1. PolyMASC Pharmaceuticals, London, UK

    G. E. Francis

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© 2000 Humana Press Inc.

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Ghetie, V., Vitetta, E.S. (2000). Chemical Construction of Immunotoxins. In: Francis, G.E., Delgado, C. (eds) Drug Targeting. Methods in Molecular Medicine™, vol 25. Humana Press. https://doi.org/10.1385/1-59259-075-6:1

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  • DOI: https://doi.org/10.1385/1-59259-075-6:1

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-531-7

  • Online ISBN: 978-1-59259-075-9

  • eBook Packages: Springer Protocols

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