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Drug Targeting

Strategies, Principles, and Applications

  • G. E. Francis
  • Cristina Delgado

Part of the Methods in Molecular Medicine™ book series (MIMM, volume 25)

Table of contents

  1. Front Matter
    Pages i-x
  2. Strategies

    1. Victor Ghetie, Ellen S. Vitetta
      Pages 1-26
    2. Steven M. Ansell, Troy O. Harasym, Paul G. Tardi, Susan S. Buchkowsky, Marcel B. Bally, Pieter R. Cullis
      Pages 51-68
    3. Dianne L. Newton, Susanna M. Rybak
      Pages 77-95
  3. Theoretical Aspects

    1. Lai-Ming Ching, Wilson William R., Baguley Bruce C.
      Pages 133-157
  4. Applications

    1. Ban An. Khaw, Vladimir P. Torchilin
      Pages 159-191
    2. Seth H. Pincus
      Pages 193-214
    3. Robert J. Kreitman, Ira Pastan
      Pages 215-226
    4. Ellen K. Wasan, Dorothy L. Reimer, Pierrot Harvie, Spencer Kong, Frances M. P. Wong, Marcel B. Bally
      Pages 255-304
  5. Back Matter
    Pages 305-318

About this book

Introduction

In Drug Targeting: Strategies, Methods, and Protocls, Gillian E. Francis and Cristina Delgado have assembled an outstanding collection of leading-edge protocols for drug targeting studies. In addition to providing detailed step-by-step instructions, the highly experienced authors review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also presented are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium, as well as methods addressing both the active and passive targeting of tumors.
Comprehensive and innovative, Drug Targeting: Strategies, Methods, and Protocols documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals.

Editors and affiliations

  • G. E. Francis
    • 1
  • Cristina Delgado
  1. 1.PolyMASC PharmaceuticalsLondonUK

Bibliographic information

  • DOI https://doi.org/10.1385/1592590756
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-531-7
  • Online ISBN 978-1-59259-075-9
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • Buy this book on publisher's site
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