Abstract
According to the current model for the subcellular compartmentalization of proteins, any protein entering the secretory pathway will be transported by bulk flow to the cell surface unless a signal mediating its organelle-specific retention is present. Endoplasmic reticulum (ER) membrane protems, such as cytochromes P450, must have a sequence or structural features that prevent transport from the ER. For some ER membrane proteins, such signals have been identified and are encoded by a short amino acid sequence such as a double lysme motif at the C-terminus of the cytoplasmic tail or positively charged residues at the N-terminus (reviewed in ref. 1). ER retention signals may mediate either the direct retention (exclusion from further transport) or retrieval from a post-ER compartment (1).
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Skorupa, E., Kemper, B. (1998). Signals for Retention of Cytochrome P450 in the Endoplasmic Reticulum. In: Phillips, I.R., Shephard, E.A. (eds) Cytochrome P450 Protocols. Methods in Molecular Biology™, vol 107. Humana Press. https://doi.org/10.1385/0-89603-519-0:251
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DOI: https://doi.org/10.1385/0-89603-519-0:251
Publisher Name: Humana Press
Print ISBN: 978-0-89603-519-5
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