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Secretion of Mammalian Proteins from Mycobacteria

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Mycobacteria Protocols

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 101))

Abstract

Mycobacterium bovis Bacille Calmette Guérin (BCG) has several features that make it desirable as a vaccine vehicle for foreign antigens. BCG is a live vaccine and stimulates a strong cell-mediated immune response, is extremely safe, and can be given at birth (1). Using recently developed tools to produce recombinant mycobacteria, BCG has been engineered to express antigens from HIV, Pneumococcus, Leuhmania, and Borrelia (2–6). Each of these strains elicits cell-mediated and/or humoral immune responses against their surrogate antigens.

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References

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Author information

Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, Cambridge, MA

    Peter J. Murray & Richard A. Young

  2. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA

    Richard A. Young

Authors
  1. Peter J. Murray
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  2. Richard A. Young
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Editor information

Editors and Affiliations

  1. London School of Hygiene and Tropical Medicine, London, UK

    Tanya Parish  & Neil G. Stoker  & 

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© 1998 Humana Press Inc., Totowa, NJ

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Murray, P.J., Young, R.A. (1998). Secretion of Mammalian Proteins from Mycobacteria. In: Parish, T., Stoker, N.G. (eds) Mycobacteria Protocols. Methods in Molecular Biology™, vol 101. Humana Press. https://doi.org/10.1385/0-89603-471-2:275

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  • DOI: https://doi.org/10.1385/0-89603-471-2:275

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-471-6

  • Online ISBN: 978-1-59259-576-1

  • eBook Packages: Springer Protocols

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